484-23-1 Usage
Description
Ophthazin, also known as Hydralazine Hydrochloride, is a medication belonging to the hydrazine class of antihypertensive agents. It is primarily used to treat high blood pressure and has been found effective in specific patient populations, such as those undergoing hemodialysis or experiencing certain conditions during pregnancy.
Uses
Used in Dialysis Patients:
Ophthazin is used as an antihypertensive agent for dialysis patients, particularly those with familial Mediterranean fever and cystinosis. It helps manage high blood pressure in these patients by relaxing blood vessels and improving blood flow, thus reducing the strain on the heart.
Used in Pregnant Patients:
Ophthazin is also used as a treatment for high blood pressure during pregnancy in patients with specific conditions like familial Mediterranean fever and cystinosis. The medication helps to lower blood pressure and prevent complications associated with hypertension in these at-risk pregnancies.
Originator
Nepresol,Novartis
Manufacturing Process
115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128
parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at
the temperature 95°C for 3 hours with stirring. After 20 minutes the
crystallization and discharging of NH3 began. The orange needles were filtered
off after cooling. The product was washed with dioxane and ethanol and
recrystallized from 3000 parts of water to yield 110 parts colorless needles of
1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were
getting a little orange color by standing because of a reaction with an air
oxygen.
Therapeutic Function
Antihypertensive
Safety Profile
Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 484-23-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 484-23:
(5*4)+(4*8)+(3*4)+(2*2)+(1*3)=71
71 % 10 = 1
So 484-23-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)