484-49-1 Usage
Description
1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE is an alkaloid that has been demonstrated to possess significant antineoplastic activity. 1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE has shown promise in the field of oncology due to its ability to inhibit tumor growth and extend the survival time of subjects with certain types of cancer.
Uses
Used in Anticancer Applications:
1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE is used as an antineoplastic agent for its ability to increase survival time in mice with leukemia. Administered intraperitoneally at doses of 25 or 50 mg/kg on alternate days or daily, it has been shown to enhance survival time by 89-229 percent compared to control animals. This suggests its potential use in the development of treatments for various types of cancer.
Used in Pharmaceutical Research and Development:
1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE is used as a compound in the synthesis of other pharmaceuticals, such as olivacine. Japanese researchers have reported the synthesis of olivacine by heating indole with 4(1-hydroxyethyl)-3-methoxymethyl-2-methylpyridine in 47 percent HBr. This indicates its utility in the creation of novel therapeutic agents and the advancement of cancer treatment options.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 27, p. 1751, 1990 DOI: 10.1002/jhet.5570270645
References
Regina et al., Cienc. Cult. (Sao Paulo), 26, 517 (1974)Synthesis:
Kametani et al., J. Chern. Soc., Perkin I, 2102 (1975)
Check Digit Verification of cas no
The CAS Registry Mumber 484-49-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 484-49:
(5*4)+(4*8)+(3*4)+(2*4)+(1*9)=81
81 % 10 = 1
So 484-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H14N2/c1-10-12-7-8-18-11(2)14(12)9-15-13-5-3-4-6-16(13)19-17(10)15/h3-9,19H,1-2H3
484-49-1Relevant articles and documents
A new efficient synthesis of pyridocarbazoles
Narasimhan,Gokhale
, p. 86 - 87 (1985)
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Total synthesis of ellipticine quinones, olivacine, and calothrixin b
Ramkumar, Nagarajan,Nagarajan, Rajagopal
, p. 736 - 741 (2014)
A direct route to the synthesis of biologically active ellipticine quinones, olivacine, and calothrixin B is described. The prominent key steps involved are Friedel-Crafts hydroxyalkylation followed by oxidation and directed ortho-lithiation reactions of readily available indole-2-carboxylate esters with appropriately substituted pyridine and quinoline carboxaldehydes.
Synthesis and activity against mycobacterium tuberculosis of olivacine and oxygenated derivatives
Schmidt, Ulrike,Theumer, Gabriele,J?ger, Anne,Kataeva, Olga,Wan, Baojie,Franzblau, Scott G.,Kn?lker, Hans-Joachim
, (2018/06/15)
The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as a key step. In a test for the inhibition of the growth of Mycobacterium tuberculosis, 9-methoxyolivacine showed the most significant inhibitory activity against Mycobacterium tuberculosis, with an MIC90 value of 1.5 μM.
