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484-94-6

484-94-6

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484-94-6 Usage

Uses

2-Fluoro-6-nitroanisole is a derivative of 2-Fluoro-6-nitrophenol (F594845). Used as plant growth regulators.

Check Digit Verification of cas no

The CAS Registry Mumber 484-94-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 484-94:
(5*4)+(4*8)+(3*4)+(2*9)+(1*4)=86
86 % 10 = 6
So 484-94-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H6FNO3/c1-12-7-5(8)3-2-4-6(7)9(10)11/h2-4H,1H3

484-94-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-fluoro-2-methoxy-3-nitrobenzene

1.2 Other means of identification

Product number -
Other names BENZENE,1-FLUORO-2-METHOXY-3-NITRO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:484-94-6 SDS

484-94-6Synthetic route

1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

3-fluoro-2-methoxyaniline
437-83-2

3-fluoro-2-methoxyaniline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 24h;94%
With platinum Hydrogenation;
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 27h;
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

N,N-diethyl-2-(2-methoxy-3-nitrophenoxy)ethanamine

N,N-diethyl-2-(2-methoxy-3-nitrophenoxy)ethanamine

Conditions
ConditionsYield
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.666667h;
Stage #2: 1-fluoro-2-methoxy-3-nitrobenzene In N,N-dimethyl-formamide at 20℃;		19%
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

1-bromo-2-methoxy-3-fluorobenzene
845829-94-9

1-bromo-2-methoxy-3-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr
2.1: sodium nitrite / water / 1 h / -5 - 0 °C
2.2: 2 h / 0 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / 2844.39 Torr
2.1: sodium nitrite; hydrogen bromide / water / 1 h / -5 - 0 °C
2.2: 2 h / 0 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2844.39 Torr
2.1: hydrogen bromide; sodium nitrite / water / 1 h / -5 - 0 °C
2.2: 2 h / 0 - 50 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4-bromo-2-fluoro-3-methoxybenzoic acid
194804-92-7

4-bromo-2-fluoro-3-methoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2844.39 Torr
2.1: sodium nitrite / water / 1 h / -5 - 0 °C
2.2: 2 h / 0 - 50 °C
3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 °C / 2844.39 Torr
2.1: sodium nitrite; hydrogen bromide / water / 1 h / -5 - 0 °C
2.2: 2 h / 0 - 50 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4-bromo-2-fluoro-3-methoxybenzoic acid chloride

4-bromo-2-fluoro-3-methoxybenzoic acid chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

ethyl 3-(4-bromo-2-fluoro-3-methoxyphenyl)-3-oxopropionate
194804-99-4

ethyl 3-(4-bromo-2-fluoro-3-methoxyphenyl)-3-oxopropionate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

7-bromo-9-cyclopropyl-8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-dione
846564-00-9

7-bromo-9-cyclopropyl-8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-dione

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
6.1: sodium hydride / dimethylformamide / 0 - 20 °C
6.2: 76 percent / dimethylformamide / 24 h / 20 °C
7.1: sodium hydride / dimethylformamide / 72 h / 75 °C
8.1: 290.9 mg / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 20 °C
9.1: sodium hydrosulfide / dimethylformamide / 1 h / 50 °C
10.1: 121.9 g / aq. NaHCO3; hydroxylamine-O-sulfonic acid / tetrahydrofuran / 2.5 h / 20 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

ethyl 7-bromo-1-cyclopropyl-8-methoxy-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
846563-98-2

ethyl 7-bromo-1-cyclopropyl-8-methoxy-2-methylsulfanyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
6.1: sodium hydride / dimethylformamide / 0 - 20 °C
6.2: 76 percent / dimethylformamide / 24 h / 20 °C
7.1: sodium hydride / dimethylformamide / 72 h / 75 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

ethyl 7-bromo-1-cyclopropyl-2-mercapto-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
846564-01-0

ethyl 7-bromo-1-cyclopropyl-2-mercapto-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
6.1: sodium hydride / dimethylformamide / 0 - 20 °C
6.2: 76 percent / dimethylformamide / 24 h / 20 °C
7.1: sodium hydride / dimethylformamide / 72 h / 75 °C
8.1: 290.9 mg / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 20 °C
9.1: sodium hydrosulfide / dimethylformamide / 1 h / 50 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

ethyl 7-bromo-1-cyclopropyl-2-methanesulfinyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
846563-99-3

ethyl 7-bromo-1-cyclopropyl-2-methanesulfinyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
6.1: sodium hydride / dimethylformamide / 0 - 20 °C
6.2: 76 percent / dimethylformamide / 24 h / 20 °C
7.1: sodium hydride / dimethylformamide / 72 h / 75 °C
8.1: 290.9 mg / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 20 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

ethyl 2-(4-bromo-2-fluoro-3-methoxybenzoyl)-3-cyclopropylamino-3-methylsulfanylacrylate

ethyl 2-(4-bromo-2-fluoro-3-methoxybenzoyl)-3-cyclopropylamino-3-methylsulfanylacrylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: H2 / Pd/C / methanol / 27 h / 20 °C
2.1: aq. HBr; NaNO2 / 0 - 5 °C
2.2: CuBr; aq. HBr / 60 °C
3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C
3.2: tetrahydrofuran; hexane / -78 - 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C
5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C
6.1: sodium hydride / dimethylformamide / 0 - 20 °C
6.2: 76 percent / dimethylformamide / 24 h / 20 °C
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

3-fluorosalicylaldehyde
394-50-3

3-fluorosalicylaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h
3: 84 percent / 48percent HBr / 4.5 h / Heating
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

fluoro-3 methoxy-2 benzaldehhyde
74266-68-5

fluoro-3 methoxy-2 benzaldehhyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

1,3-difluoro-2-methoxy-5-nitrobenzene
392-25-6

1,3-difluoro-2-methoxy-5-nitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

3,5-difluoro-4-methoxyaniline
363-47-3

3,5-difluoro-4-methoxyaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

3,5-difluoro-4-methoxyphenol
443-42-5

3,5-difluoro-4-methoxyphenol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
5: aqueous H2SO4; aqueous CuSO4-solution; xylene / Diazotization
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4-nitro-benzoic acid-(3-fluoro-2-methoxy-anilide)
345-47-1

4-nitro-benzoic acid-(3-fluoro-2-methoxy-anilide)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: platinum / Hydrogenation
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4-nitro-benzoic acid-(3,5-difluoro-4-methoxy-anilide)
363-48-4

4-nitro-benzoic acid-(3,5-difluoro-4-methoxy-anilide)

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

5-(2,6-diiodo-4-nitro-phenoxy)-1,3-difluoro-2-methoxy-benzene
348-92-5

5-(2,6-diiodo-4-nitro-phenoxy)-1,3-difluoro-2-methoxy-benzene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
5: aqueous H2SO4; aqueous CuSO4-solution; xylene / Diazotization
6: K2CO3; pentanone-(2)
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4,4'-dimethoxy-3,3',5,5'-tetrafluoroazoxybenzene
499-43-4

4,4'-dimethoxy-3,3',5,5'-tetrafluoroazoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
View Scheme
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

4-(3,5-difluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride
400-84-0

4-(3,5-difluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
3: concentrated H2SO4; HNO3
4: platinum; methanol / Hydrogenation
5: aqueous H2SO4; aqueous CuSO4-solution; xylene / Diazotization
6: K2CO3; pentanone-(2)
7: tin (II)-chloride; acetic acid
View Scheme

484-94-6Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

-

Paragraph 0192, (2016/10/06)

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

-

Page/Page column 83, (2013/03/26)

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

-

Page/Page column 51-53, (2008/06/13)

The invention provides certain compounds and salts of Formula I and Formula II:which possess antimicrobial activity. The invention also provides novel synthetic intermediatesuseful in making compounds of Formula I and Formula II. The variables A1, R2, R3, R5, R6, R7, A8, and Rg are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

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