4842-49-3

Basic information

• Product Name: (R)-2-(4-methoxyphenyl)propionic acid
• Synonyms: (R)-2-(4-methoxyphenyl)propionic acid
• CAS NO: 4842-49-3
• Molecular Weight: 180.203
• Mol File: 4842-49-3.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-methoxyphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-methoxyphenyl)propionic acid(4842-49-3)
• EPA Substance Registry System: (R)-2-(4-methoxyphenyl)propionic acid(4842-49-3)

Safety Data

• Hazardous Substances Data: 4842-49-3(Hazardous Substances Data)

Upstream product

• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 82520-34-1 2-(4'-methoxyphenyl)propane-1,3-diol 
• 51747-42-3 2-(4-methoxy-phenyl)-acrylic acid 
• 138623-00-4 tert-butyl α-(4-methoxyphenyl)propionate 
• 64-18-6 formic acid 
• 768-60-5 4-methoxyphenylacetylen 
• 5405-83-4 (R)-2-(4-methoxyphenyl)propanal 
• 637-69-4 4-Methoxystyrene 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 1333468-58-8 (S)-3-((R)-2-(4-methoxyphenyl)propanoyl)-4-benzyloxazolidin-2-one 
• 143589-97-3 (4S)-3-<2-(4-Methoxyphenyl)-1-oxoethyl>-4-(phenylmethyl)-2-oxazolidinone 
• 62784-66-1 bis(1-naphthyl)methanol 
• 23197-67-3 diethyl 2-(4-methoxyphenyl)malonate 
• 131605-40-8 Acetic acid (S)-3-hydroxy-2-(4-methoxy-phenyl)-propyl ester 

Downstream Products

• 50415-73-1 methyl (R)-2-(4-methoxyphenyl)propionate 
• 133809-11-7 (R)-(-)-2-(4'-methoxyphenyl)propionamide 

Relevant articles and documents

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens

We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.

Iron-catalysed enantioselective Suzuki-Miyaura coupling of racemic alkyl bromides

The first iron-catalysed enantioselective Suzuki-Miyaura coupling reaction has been developed. In the presence of catalytic amounts of FeCl2 and (R,R)-QuinoxP?, lithium arylborates are cross-coupled with tert-butyl α-bromopropionate in an enantioconvergent manner, enabling facile access to various optically active α-arylpropionic acids including several nonsteroidal anti-inflammatory drugs (NSAIDs) of commercial importance. (R,R)-QuinoxP? is specifically able to induce chirality when compared to analogous P-chiral ligands that give racemic products, highlighting the critical importance of transmetalation in the present asymmetric cross-coupling system.

Spirobenzylamine-Phosphine, Preparation Method Therefor And Use Thereof

The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7′-diarylphosphino-1,1′-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.