485807-07-6

Basic information

• Product Name: 3-Isoxazolepropanoicacid,5-amino-,methylester(9CI)
• Synonyms: 3-Isoxazolepropanoicacid,5-amino-,methylester(9CI)
• CAS NO: 485807-07-6
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.17
• Product Categories: OXAZOLE
• Mol File: 485807-07-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Isoxazolepropanoicacid,5-amino-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolepropanoicacid,5-amino-,methylester(9CI)(485807-07-6)
• EPA Substance Registry System: 3-Isoxazolepropanoicacid,5-amino-,methylester(9CI)(485807-07-6)

Safety Data

• Hazardous Substances Data: 485807-07-6(Hazardous Substances Data)

Usage

Compound type

Methyl ester derivative

Derived from

3-Isoxazolepropanoic acid, a heterocyclic compound

Potential properties

Anticonvulsant and neuroprotective

Studied for

Treatment of neurological disorders and epilepsy

Potential mechanism of action

Modulator of the GABAergic system

Bioavailability enhancement

Methyl ester form may improve absorption in the body

Need for further research and testing

Fully understand therapeutic uses

Upstream product

• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 
• 204773-84-2 methyl 4-(bis((trimethylsilyl)oxy)amino)pent-4-enoate 

Relevant articles and documents

Chemistry of N,N-bis(silyloxy)enamines 7. Quaternization of tertiary amines and nitrogen-containing heterocycles by N,N-bis(silyloxy)enamines

Coupling of N,N-bis(silyloxy)enamines with tertiary amines and nitrogen-containing heterocycles affording the corresponding functionalized ammonium or iminium salts was studied. The area of its application was determined, and optimal procedures for the synthesis of the target products were proposed. The mechanism including the formation of conjugated nitroso alkene or a silylnitrosonium cation as key intermediates is discussed.

Reactions of N,N-bis(siloxy)enamines with trimethylsilyl cyanide: Aliphatic nitro compounds as convenient precursors of 5-aminoisoxazoles

A convenient procedure was developed for the synthesis of 5-aminoisoxazoles by the consecutive double silylation and cyanation of aliphatic nitro compounds.