485841-46-1

Basic information

• Product Name: 2-Pyridinecarboxamide, N-methyl-4-[4-(methylamino)-3-nitrophenoxy]-
• CAS NO: 485841-46-1
• Molecular Formula: C14H14N4O4
• Molecular Weight: 302.29
• Mol File: 485841-46-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, N-methyl-4-[4-(methylamino)-3-nitrophenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, N-methyl-4-[4-(methylamino)-3-nitrophenoxy]-(485841-46-1)
• EPA Substance Registry System: 2-Pyridinecarboxamide, N-methyl-4-[4-(methylamino)-3-nitrophenoxy]-(485841-46-1)

Safety Data

• Hazardous Substances Data: 485841-46-1(Hazardous Substances Data)

Upstream product

• 485841-45-0 4-(4-amino-3-nitro-phenoxy)-pyridine-2-carboxylic acid methylamide 
• 77-78-1 dimethyl sulfate 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Downstream Products

• 485841-47-2 4-(3-amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide 

Relevant articles and documents

Design and synthesis of orally bioavailable benzimidazoles as raf kinase inhibitors

A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS

The invention relates to compounds of the formulae (I) to (III) wherein the substituents are as defined in the specification. These compounds have kinase inhibitory activity, such as VEGFR/KDR inhibitory activity. Accordingly, the compounds of the formulae (I) to (III) would be useful in the prevention and treatment of angiogenesis related disorders, ophthalmological conditions, proliferative diseases, inflammatory diseases, and other pathological conditions as described in the specification.