486-28-2 Usage
Description
Fraxinol is a naturally occurring coumarin that was originally isolated from the bark of the Ash tree. It has demonstrated the ability to inhibit the growth of certain cancer cell lines, such as GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells, with IC50 values of 193 and 165 μM, respectively. Additionally, Fraxinol has been shown to enhance barbiturate-induced sleep in rats and rabbits, indicating its potential use in various applications.
Uses
Used in Pharmaceutical Industry:
Fraxinol is used as an anticancer agent for its ability to inhibit the growth of specific cancer cell lines, including GLC-4 small cell lung carcinoma and COLO 320 colorectal cancer cells. Its potential in this application is supported by its demonstrated inhibitory effects on cancer cell growth.
Used in Neuropharmacology:
Fraxinol is used as a potentiator of barbiturate-induced sleep in rats and rabbits, suggesting its potential application in the field of neuropharmacology for the enhancement of sleep-inducing effects of certain medications.
Note: The provided materials do not mention any specific use of Fraxinol in drug delivery systems or any other industries. The uses listed are based on the information given in the materials. If there are additional applications or industries where Fraxinol is used, they would need to be provided in the materials for inclusion in the response.
Check Digit Verification of cas no
The CAS Registry Mumber 486-28-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 486-28:
(5*4)+(4*8)+(3*6)+(2*2)+(1*8)=82
82 % 10 = 2
So 486-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)11(15-2)10(8)13/h3-5,13H,1-2H3
486-28-2Relevant articles and documents
Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells
Riveiro, Maria E.,Maes, Dominick,Vazquez, Ramiro,Vermeulen, Monica,Mangelinckx, Sven,Jacobs, Jan,Debenedetti, Silvia,Shayo, Carina,De Kimpe, Norbert,Davio, Carlos
scheme or table, p. 6547 - 6559 (2009/12/09)
The presumption that some coumarins might be lead compounds in the search for new differentiation agents against leukemia is based on the fact that natural coumarins, 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C-2) and 5-methoxy-6,7-methylenedioxycoumarin (C-1) inhibit proliferation and induce differentiation in U-937 cells [Riveiro, M. E.; Shayo, C.; Monczor, F.; Fernandez, N.; Baldi, A.; De Kimpe, N.; Rossi, J.; Debenedetti, S.; Davio, C. Cancer Lett. 2004, 210, 179-188]. These promising findings prompted us to investigate the anti-leukemia activity of a broader range of related polyoxygenated coumarins. Twenty related natural or synthetically prepared coumarins, including a range of 5-substituted ayapin derivatives which have become easy accessible via newly developed synthesis methods, were evaluated, where treatments with 5-(2,3-dihydroxy-3-methylbutoxy)-6,7-methylenedioxycoumarin (D-3) and 5-(2-hydroxy-3-methoxy-3-methylbutoxy)-6,7-methylenedioxycoumarin (D-2) were able to inhibit the cell growth and induce the differentiation of U-937 cells after 48 h treatment. These results provide insight into the correlation between some structural properties of polyoxygenated coumarins and their in vitro leukemic differentiation activity.
Coumarins from bark of Fraxinus japonica and F. mandshurica var. japonica
Tsukamoto,Hisada,Nishibe
, p. 4069 - 4073 (2007/10/02)
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