486406-56-8

Basic information

• Product Name: methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate
• Synonyms: methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate
• CAS NO: 486406-56-8
• Molecular Weight: 321.419
• Mol File: 486406-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate(486406-56-8)
• EPA Substance Registry System: methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate(486406-56-8)

Safety Data

• Hazardous Substances Data: 486406-56-8(Hazardous Substances Data)

Upstream product

• 6366-06-9 1-(3,5-dimethylphenyl)acetylene 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 648894-30-8 methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate 
• 486406-57-9 methyl 2-[2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropanoate 

Relevant articles and documents

Enantiospecific and regioselective opening of 2-alkyl nosylaziridines by indoles mediated by boron trifluoride. Application to a practical synthesis of a GnRH antagonist

An efficient, high yield process for the synthesis of a GnRH antagonist has been developed. We have demonstrated that under boron trifluoride mediation, nosyl aziridines will react with 2-arylindole derivatives to afford β-substituted tryptamines in an enantiospecific process with remarkably high regioselectivity. The scope of the reaction was explored with several 2-substituted nosyl aziridines. The key reaction was developed expressly for the GnRH antagonist program and has been demonstrated on 40 kilogram scale.