487-41-2

Basic information

• Product Name: FORSYTHIN
• Synonyms: FORSYTHIN PHILLYRIN;dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl;Phillyroside;Phyllyrin;β-D-Glucopyranoside,4-[(1S,3aR,4R,6aR)-4-(3,4-;(1S)-1β-[4-(β-D-Glucopyranosyloxy)-3-methoxyphenyl]-4α-(3,4-dimethoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan;PHEOPHYTHIN A (SH);Chionanthin
• CAS NO: 487-41-2
• Molecular Formula: C₂₇H₃₄O₁₁
• Molecular Weight: 534.55
• Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Piperidines ,Homopiperidines
• Mol File: 487-41-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: approximate 157℃
• Boiling Point: 730.4 °C at 760 mmHg
• Flash Point: 395.5 °C
• Appearance: /
• Density: 1.361 g/cm³
• Vapor Pressure: 2.14E-22mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.81±0.70(Predicted)
• CAS DataBase Reference: FORSYTHIN(CAS DataBase Reference)
• NIST Chemistry Reference: FORSYTHIN(487-41-2)
• EPA Substance Registry System: FORSYTHIN(487-41-2)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 487-41-2(Hazardous Substances Data)

Usage

Description

FORSYTHIN, also known as Forsythia suspensa, is a plant-derived compound with various bioactive properties. It is characterized by its ability to modulate immune responses, exhibit anti-inflammatory and antioxidant activities, and possess antimicrobial properties. These characteristics make FORSYTHIN a versatile compound with potential applications in the pharmaceutical, cosmetic, and food industries.

Uses

Used in Pharmaceutical Applications:
FORSYTHIN is used as an immunomodulatory agent for its ability to regulate immune responses, making it a potential candidate for treating autoimmune diseases and enhancing the body's defense against infections.
FORSYTHIN is used as an anti-inflammatory agent for its capacity to reduce inflammation, which can be beneficial in managing conditions like arthritis and other inflammatory disorders.
FORSYTHIN is used as an antioxidant agent for its ability to neutralize free radicals, which can help protect cells from oxidative damage and contribute to the prevention of various diseases.
Used in Cosmetic Applications:
FORSYTHIN is used as an active ingredient in skincare products for its anti-inflammatory and antioxidant properties, which can help soothe irritated skin and protect against environmental stressors.
Used in Food Industry:
FORSYTHIN is used as a natural preservative for its antimicrobial properties, which can help extend the shelf life of perishable food products and maintain their quality.
Used in Anti-obesity Applications:
FORSYTHIN is used as an anti-obesity agent for its ability to attenuate tumor necrosis factor secreted from macrophages, which play an important role in adipocyte dysfunctions, contributing to weight management and overall health.

InChI:InChI=1/C27H34O11/c1-32-17-6-4-13(8-19(17)33-2)25-15-11-36-26(16(15)12-35-25)14-5-7-18(20(9-14)34-3)37-27-24(31)23(30)22(29)21(10-28)38-27/h4-9,15-16,21-31H,10-12H2,1-3H3/t15-,16-,21+,22+,23-,24+,25?,26+,27+/m0/s1

Upstream product

• 186581-53-3 diazomethane 
• 24404-49-7 (3R,4S,5S,6R)-2-{4-[(1S,3aR,4S,6aR)-4-(4-Hydroxy-3-methoxy-phenyl)-tetrahydro-furo[3,4-c]furan-1-yl]-2-methoxy-phenoxy}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 

Downstream Products

• 487-39-8 phillygenin 
• 487-39-8 (+)-pinoresinol monomethyl ether 

Relevant articles and documents

Chemical synthesis method of phillyrin

The present invention relates to a method for chemical synthesis of phillyrin. According to the method, a glycosyl acceptor phillygenin and a glycosyl donor are dissolved in an organic solvent, a glycosylation reaction is performed to prepare tetra acyl phillyrin, the tetra acyl phillyrin is dissolved in an organic solvent, sodium methylate is added, a deacylation reaction is performed, an acidic pH value adjusting agent is added to adjust the pH value of the reaction mixture to achieve a neutral state, and finally a purification treatment is performed to obtain the product. According to the present invention, the advanced and practical characteristics of the production method comprise convenient raw material source, cheap and easily-available catalyst for the glycosylation reaction, significantly-reduced preparation cost, and industrial production achieving.