487-58-1Relevant articles and documents
L-Hypaphorine and D-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue
Yonekawa, Murilo K.A.,Penteado, Bruna de B.,Dal'Ongaro Rodrigues, Amanda,Louren?o, Estela M.G.,Barbosa, Euzébio G.,das Neves, Silvia C.,de Oliveira, Rodrigo J.,Marques, Maria R.,Silva, Denise B.,de Lima, Dênis P.,Beatriz, Adilson,Oses, Jean P.,dos S. Jaques, Jeandre A.,Santos, Edson dos A. dos
supporting information, (2021/07/10)
Acetylcholinesterase (AChEis) inhibitors are used to treat neurodegenerative diseases like Alzheimer's disease (AD). L-Hypaphorine (L-HYP) is a natural indole alkaloid that has been shown to have effects on the central nervous system (CNS). The goal of this research was to synthesize L-HYP and D-HYP and test their anticholinesterasic properties in rat brain regions. L-HYP suppressed acetylcholinesterase (AChE) activity only in the cerebellum, whereas D-HYP inhibited AChE activity in all CNS regions studied. No cytotoxic effect on normal human cells (HaCaT) was observed in the case of L-HYP and D-HYP although an increase in cell proliferation. Molecular modeling studies revealed that D-HYP and L-HYP have significant differences in their binding mode positions and interact stereospecifically with AChE's amino acid residues.
Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis
Vit, Allegra,Misson, La?titia,Blankenfeldt, Wulf,Seebeck, Florian P.
, p. 119 - 125 (2015/03/03)
Ergothioneine is an N-α-trimethyl-2-thiohistidine derivative that occurs in human, plant, fungal, and bacterial cells. Biosynthesis of this redox-active betaine starts with trimethylation of the α-amino group of histidine. The three consecutive methyl transfers are catalyzed by the S-adenosylmethionine-dependent methyltransferase EgtD. Three crystal structures of this enzyme in the absence and in the presence of N-α-dimethylhistidineand S-adenosylhomocysteine implicate a preorganized array of hydrophilic interactions as the determinants for substrate specificity and apparent processivity. We identified two active site mutations that change the substrate specificity of EgtD 107-fold and transform the histidine-methyltransferase into a proficient tryptophan-methyltransferase. Finally, a genomic search for EgtD homologues in fungal genomes revealed tyrosine and tryptophan trimethylation activity as a frequent trait in ascomycetous and basidomycetous fungi.
Betaines derived from amino and hydrazino acids as phase transfer catalysts
Goldberg, Yuri,Abele, Edgars,Bremanis, Gunars,Trapenciers, Peteris,Gaukhman, Alexander,Popelis, Juris,Gomtsyan, Artur,Kalvins, Ivars,Shymanska, Mariya,Lukevics, Edmunds
, p. 1911 - 1922 (2007/10/02)
Betaines derived from α-, β- and γ-amino acids (obtained by alkylation of the corresponding amino acids with O-methyl-N.N'- diisopropylisourea) as well as β-hydrazino acids (prepared by dehydrohalogenative hydrolysis of methyl 3-(2-alkyl-2,2-dimethylhydra