487003-20-3

Basic information

• Product Name: 1H-Indole-2,3-dione, 6-methoxy-1-(phenylmethyl)-
• CAS NO: 487003-20-3
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol File: 487003-20-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2,3-dione, 6-methoxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2,3-dione, 6-methoxy-1-(phenylmethyl)-(487003-20-3)
• EPA Substance Registry System: 1H-Indole-2,3-dione, 6-methoxy-1-(phenylmethyl)-(487003-20-3)

Safety Data

• Hazardous Substances Data: 487003-20-3(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 52351-75-4 6-methoxyisatin 
• 100-39-0 benzyl bromide 

Downstream Products

• 104598-83-6 1-benzyl-6-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 91444-16-5 6-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 158611-24-6 6-methoxy-2-(4-methoxyphenyl)-1H-indole-3-carbaldehyde 
• 1103774-26-0 N'-[(3Z)-1-benzyl-6-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide 
• 487003-27-0 1-benzyl-1,3-dihydro-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2H-indol-2-one 
• 487003-24-7 1-benzyl-1,3-dihydro-6-hydroxy-2H-indol-2-one 
• 487003-22-5 1-benzyl-1,3-dihydro-6-methoxy-2H-indol-2-one 

Relevant articles and documents

Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones

The aromatic nitrogen atoms of heteroarylaldehydes are activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products are afforded in good to excellent yields and optical purities. Our reaction involves the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibit excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichemicals for plant protection.

Divergent and Orthogonal Approach to Carbazoles and Pyridoindoles from Oxindoles via Indole Intermediates

The previously unexplored Grignard addition to oxindoles provides a regiospecific approach to 2- and 2,3-disubstituted indole derivatives in high yields via a one-pot aromatization driven dehydration pathway. This method allows a convenient preparation of diallyl indoles that are used as ring-closing metathesis (RCM) precursors for the orthogonal synthesis of pyrido[1,2-a]indoles and carbazoles. The synthetic utility of this method is illustrated by the synthesis of a microtubulin inhibitor and naturally occurring carbazole alkaloids.

HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS

Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.