4871-28-7

Basic information

• Product Name: Benzaldehyde, 4-nitro-, [4-(4-methoxyphenyl)-2-thiazolyl]hydrazone
• CAS NO: 4871-28-7
• Molecular Formula: C17H14N4O3S
• Molecular Weight: 354.389
• Mol File: 4871-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-nitro-, [4-(4-methoxyphenyl)-2-thiazolyl]hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-nitro-, [4-(4-methoxyphenyl)-2-thiazolyl]hydrazone(4871-28-7)
• EPA Substance Registry System: Benzaldehyde, 4-nitro-, [4-(4-methoxyphenyl)-2-thiazolyl]hydrazone(4871-28-7)

Safety Data

• Hazardous Substances Data: 4871-28-7(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 5470-48-4 para-nitrobenzaldehyde thiosemicarbazone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

One PotTwo Step Synthesis of 2-Arylidenehydrazinyl-4-arylthiazole

An efficient, simple one pot, two step procedure has been developed for the synthesis of 2-arylidenehydrazinyl-4-arylthiazole. The reaction of aromatic aldehyde, thiosemicarbazide and phenacyl bromide gave the desired products in good yield. The first reaction product thiosemicarbazone was obtained on reaction with aromatic aldehyde and thiosemicarbazide; without isolating this directly treated with phenacyl bromide in presence of acidic buffer at room temperature desired product was obtained with simple workup procedure.

Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring

A series of arylidene-2-(4-(4-methoxy/bromophenyl) thiazol-2-yl) hydrazines (4a-z) and 1-(4-(4-methoxy/bromophenyl) thiazol-2-yl)-2-cyclohexylidene/cyclopentylidene hydrazines (5a-b/6a-b) were synthesized, characterized and screened for their antimicrobial activities. The structures of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. Both the anti-bacterial and anti-fungal activities with MIC values of compounds were evaluated. The results of anti-bacterial screening reveal that among all the compounds screened eight compounds showed moderate to good anti-bacterial activity while ten of the newly synthesized compounds displayed good to excellent anti-fungal activity. Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 μg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz. Candida albicans, Cryptococcus neoformans and Aspergillus flavus.