4878-20-0

Basic information

• Product Name: Propanoyl chloride, 2-(4-chlorophenoxy)-
• Synonyms: 2-(4-Chloro-phenoxy)-propionyl chloride;2-(4-chlorophenoxy)-propionyl chloride;α-[(R,S)-p-chlorophenoxy]propionyl chloride
• CAS NO: 4878-20-0
• Molecular Formula: C9H8Cl2O2
• Molecular Weight: 219.067
• Mol File: 4878-20-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanoyl chloride, 2-(4-chlorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoyl chloride, 2-(4-chlorophenoxy)-(4878-20-0)
• EPA Substance Registry System: Propanoyl chloride, 2-(4-chlorophenoxy)-(4878-20-0)

Safety Data

• Hazardous Substances Data: 4878-20-0(Hazardous Substances Data)

Upstream product

• 1193-00-6 sodium 4-chlorophenolate 
• 3307-39-9 2-(4-chlorophenoxy)propionic acid 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 104148-56-3 1-[2-(4-chlorophenoxy)-propionyloximino]-hexanephosphonic acid diethyl ester 
• 92471-63-1 (R)-2-methyl-2-(4-chlorophenoxy)ethanol 
• 63650-24-8 2-(4-chlorophenoxy)-1-propanol 
• 1174133-46-0 1-[2-(4-chlorophenoxy)propanoyl]-3-(4-fluorophenyl)imidazolidine-2,4-dione 
• 1174133-47-1 1-[2-(4-chlorophenoxy)propanoyl]-3-(4-chlorophenyl)imidazolidine-2,4-dione 
• 1174133-45-9 1-[2-(4-chlorophenoxy)propanoyl]-3-phenylimidazolidine-2,4-dione 
• 63294-09-7 2-{4-[2-(2-(4-chlorophenoxy)-propionylamino)-ethyl]-phenoxy}-2-methylpropionic acid 
• 3307-39-9 (S)-2-(4-chlorophenoxy)propionic acid 
• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 
• 155156-11-9 2-(4-Chloro-phenoxy)-propionic acid (1R,3S,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester 
• 95262-84-3 2-(4-chlorophenoxy)propanoic acid methyl ester 
• 65569-34-8 5-Chloro-4-[2-(4-chloro-phenoxy)-propionylamino]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide 

Relevant articles and documents

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

Direct resolution of α-monoalkyl-α-aryloxyacetic acids via ester or imide derivatives

This paper describes a simple procedure for the resolution of racemic α-monoalkyl α-aryloxyacetic acids, using the chromatographic separation of their covalent derivatives. (R)-Ethyl mandelate, (R)-pantolactone and (S)-4-(1-methylethyl)-2-oxazolidinone are the resolving agents involved in the formation of equimolecular diastereomeric mixtures of esters or imides. Chromatographic resolutions were performed by means of gas chromatography (GC), thin-layer chromatography (TLC) and flash chromatography. Successive hydrolysis of separated diastereomers provided optically pure aryloxyacetic acids.

Biological Evaluation of some New Nitrophenoxy/Halophenoxyaeetyl/Propionyl-2-mercaptobenzothiazoles

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