488149-34-4

Basic information

• Product Name: 2-chloro-N-methoxy-N-methylnicotinamide
• Synonyms: 2-chloro-N-methoxy-N-methylnicotinamide;N-Methoxy-N-methyl 2-chloronicotinamide;2-Chloro-N-methoxy-N-methylpyridine-3-carboxamide;2-chloro-N-methoxy-N-methyl-3-pyridinecarboxamide
• CAS NO: 488149-34-4
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.62226
• Mol File: 488149-34-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 85～87℃
• Boiling Point: 365.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.283±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerated.
• PKA: -1.51±0.10(Predicted)
• CAS DataBase Reference: 2-chloro-N-methoxy-N-methylnicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-methoxy-N-methylnicotinamide(488149-34-4)
• EPA Substance Registry System: 2-chloro-N-methoxy-N-methylnicotinamide(488149-34-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 488149-34-4(Hazardous Substances Data)

Usage

General Description

2-chloro-N-methoxy-N-methylnicotinamide is a chemical compound with the molecular formula C8H10ClNO2. It is a derivative of nicotinamide, containing a chlorine atom and a methoxy group attached to the nitrogen atom. 2-chloro-N-methoxy-N-methylnicotinamide is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and active pharmaceutical ingredients (APIs). It has been studied for its potential pharmacological properties, including anti-inflammatory and analgesic effects. Its chemical structure and properties make it a valuable building block in the development of new pharmaceuticals for various medical applications.

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 16645-06-0 N,N-dimethylhydroxylamine hydrochloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 2942-59-8 2-chloronicotinic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 30289-28-2 N-methoxy-N-methylcarbamoyl chloride 

Downstream Products

• 1146523-97-8 1-(2-chloropyridin-3-yl)-3-(3-fluorophenyl)prop-2-yn-1-one 
• 791119-13-6 3-(4-chlorophenyl-2-chloropyrid-3-ylmethoxy)azetidine 
• 1186316-75-5 VER-156085 
• 1186316-73-3 VER-156084 
• 1186316-76-6 VER-24052 
• 1357306-02-5 C₁₆H₁₃Cl₃N₂O₂ 
• 791119-12-5 1-benzhydyryl-3-(4-chlorophenyl-2-chloropyrid-3-ylmethoxy)azetidine 
• 1357305-47-5 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}pyrrolidin-1-ylmethanone 
• 1357305-50-0 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}morpholin-4-ylmethanone 
• 1357305-51-1 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(2-methylpiperidin-1-yl)methanone 
• 1357305-52-2 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(3-methylpiperidin-1-yl)methanone 
• 1357305-53-3 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(4-methylpiperidin-1-yl)methanone 
• 1357305-54-4 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(4-methylpiperazin-1-yl)methanone 
• 1357305-55-5 {3-[(4-chlorophenyl)(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}(4-benzylpiperidin-1-yl)methanone 

Relevant articles and documents

A Novel Synthesis of 1-Alkyl-2-phenyl-1,8-naphthyridin-4-one

Provided is a novel method for manufacturing 1-alkyl-2-phenyl-1,8-naphthyridin-4-one from 2-chloronicotinic acid. According to the present invention, 1-alkyl-2-phenyl-1,8-naphthyridin-4-one can be synthesized through simple reaction conditions and simple

A novel synthesis of 1-alkyl-2-phenyl-(2,3-dihydro-) 1,8-naphthyridin-4-ones from 2-chloronicotinic acid

-

Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents

A series of N-phenyl-imidazo[4,5-b]pyridin-2-amines, 4-indazolyl-N- phenylpyrimidin-2-amines and N-phenyl-4-pyrazolo[3,4-b]pyridin-pyrimidin-2- amines have been synthesized. Their anti-proliferative activities were tested in HCT-116 human colon carcinoma and MCF-7 breast carcinoma cell lines. Many exhibited potent anti-proliferative and CDK9 inhibitory activities. A lead compound 18b demonstrated the ability to reduce the level of Mcl-1 anti-apoptotic protein, to activate caspase 3/7 and induce cancer cell apoptosis.