488835-85-4Relevant articles and documents
NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS
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Page/Page column 95-96, (2008/06/13)
The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
Diastereoselective synthesis of all stereoisomers of β-methoxytyrosine, a component of papuamides
Okamoto, Naoki,Hara, Osamu,Makino, Kazuishi,Hamada, Yasumasa
, p. 9210 - 9215 (2007/10/03)
β-Methoxytyrosine (β-OMeTyr) is a stereoundefined component of papuamides A and B, novel cyclodepsipeptides, with anti-HIV and cytotoxic activities. For structural determination and total synthesis of papuamides, all stereoisomers of β-OMeTyr were stereos