491-40-7

Basic information

• Product Name: octahydro-4H-quinolizin-4-one
• Synonyms: 4H-quinolizin-4-one, octahydro-
• CAS NO: 491-40-7
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.2215
• Mol File: 491-40-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 274.493°C at 760 mmHg
• Flash Point: 123.206°C
• Density: 1.062g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: octahydro-4H-quinolizin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: octahydro-4H-quinolizin-4-one(491-40-7)
• EPA Substance Registry System: octahydro-4H-quinolizin-4-one(491-40-7)

Safety Data

• Hazardous Substances Data: 491-40-7(Hazardous Substances Data)

Usage

General Description

Octahydro-4H-quinolizin-4-one, also known as tetrahydroisoquinolin-4-one, is a chemical compound with a bicyclic structure containing a quinolizine ring. It is a colorless, crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The compound has been studied for its potential pharmacological properties, including its ability to act as an inhibitor of enzymes and receptors in the human body. Additionally, it has been investigated for its potential applications in the treatment of neurological disorders and as an anti-inflammatory agent. Octahydro-4H-quinolizin-4-one has also been studied as a precursor for the synthesis of various heterocyclic compounds with potential medicinal properties.

Upstream product

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Downstream Products

• 622-39-9 2-propylpyridine 
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Relevant articles and documents

Studies on 1-azabicyclo compounds. VI. A convenient synthesis and dehydrogenation of octahydroquinolizine

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Palladium-Catalyzed Dearomative Cyclocarbonylation by C-N Bond Activation

A fundamentally novel approach to bioactive quinolizinones is based on the palladium-catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene-substituted allylamines into bioactive quinolizinones in good to excellent yields. This transformation represents the first dearomative carbonylation and is proposed to proceed by palladium-catalyzed C-N bond activation, dearomatization, CO insertion, and a Heck reaction.

Synthesis of an N-substituted lactam using an intramolecular schmidt reaction: Formation of 2,3,11,11a-tetrahydro-1H-benzo[d]pyrrolo[1,2-a]azepin-5(6H)-one

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