491-79-2

Basic information

• Product Name: 2-Hydroxy-6-[2-(4-hydroxyphenyl)vinyl]benzoic acid
• Synonyms: 2-Hydroxy-6-[2-(4-hydroxyphenyl)vinyl]benzoic acid;Hydrangeic acid
• CAS NO: 491-79-2
• Molecular Formula: C₁₅H₁₂O₄
• Molecular Weight: 256.25
• Mol File: 491-79-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Hydroxy-6-[2-(4-hydroxyphenyl)vinyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-6-[2-(4-hydroxyphenyl)vinyl]benzoic acid(491-79-2)
• EPA Substance Registry System: 2-Hydroxy-6-[2-(4-hydroxyphenyl)vinyl]benzoic acid(491-79-2)

Safety Data

• Hazardous Substances Data: 491-79-2(Hazardous Substances Data)

Upstream product

• 480-47-7 hydrangenol 
• 507480-02-6 5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 438187-08-7 2, 2, 5-trimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 567-61-3 2-hydroxy-6-methylbenzoic acid 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 

Downstream Products

• 63877-76-9 (E)-4-<2-(3-hydroxyphenyl)ethenyl>phenol 
• 23255-59-6 lunularic acid 
• 52528-89-9 3,4'-bis-benzoyloxy-bibenzyl 
• 37116-80-6 lunularin 
• 183619-44-5 8-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isochroman-1-one 
• 183619-48-9 8-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-isochromen-1-one 
• 80458-94-2 3'-Deoxythunberginol A 
• 480-47-7 hydrangenol 
• 157598-00-0 (+/-)-hydromacrophyllol B 
• 157598-00-0 (+/-)-hydromacrophyllol A 
• 113345-84-9 methyl 2-methoxy-6-[2-(4-methoxyphenyl)ethenyl]benzoate 

Relevant articles and documents

Valuable building block for the synthesis of lunularic acid, hydrangeic acid and their analogues

A new functionalised sulphone-based building block has been synthesised that enabled C-C bond formation through Julia olefination. The utility of developed building block was demonstrated by successful synthesis of two natural products lunularic acid, hydrangeic acid and initial libraries of their analogues.

Development of bioactive functions in Hydrangeae Dulcis Folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: Structures and inhibitory activity on histamine release of hydramacrophyllols A and B

Lactonization reaction of 2-carboxystilbene mediated by copper(II) chloride proceeded regiospecifically to give the five-membered lactone, while the bromolactonizations using N-bromosuccinimide and anodic oxidation were found to furnish the six-membered lactone. Using these regiospecific lactonization reactions as a key step, antiallergic and antimicrobial isocoumarins and the benzylidenephthalides thunberginols A and F and their 3'-deoxyanalogs were synthesized from phyllodulcin and hydrangenol. Two phthalides called hydramacrophyllols A and B were isolated from Hydrangeae Dulcis Folium and their stereostructures were determined on the basis of physicochemical and chemical evidence, which included the syntheses of hydramacrophyllols A and B from hydrangenol by the application of the lactonization method using copper(II) chloride. In addition, hydramacrophyllols A and B were found to exhibit an inhibitory effect on the histamine release from rat peritoneal exudate cells induced by antigen- antibody reaction.