491024-78-3

Basic information

• Product Name: Benzamide, N-[(1S)-2-hydroxy-1-methylethyl]-2-nitro-
• CAS NO: 491024-78-3
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.216
• Mol File: 491024-78-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[(1S)-2-hydroxy-1-methylethyl]-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[(1S)-2-hydroxy-1-methylethyl]-2-nitro-(491024-78-3)
• EPA Substance Registry System: Benzamide, N-[(1S)-2-hydroxy-1-methylethyl]-2-nitro-(491024-78-3)

Safety Data

• Hazardous Substances Data: 491024-78-3(Hazardous Substances Data)

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 2749-11-3 (S)-Alaninol 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 491024-68-1 4-chloro-2,6-bis[2-((4S)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl)phenyl]carbamoylpyridine 
• 491024-87-4 (4S)-4-methyl-2-(2-nitrophenyl)-4,5-dihydro-1,3-oxazole 
• 209850-74-8 2-[(4S)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]aniline 
• 491024-82-9 N-(2-chloro-(1S)-1-methylethyl)-2-nitrobenzamide 

Relevant articles and documents

Dynamic helical chirality of an intramolecularly hydrogen-bonded bisoxazoline

The synthesis and conformational properties of 2,6-bis-[2-((4S)-4-methyl-4,5-dihydro-1,3-oxazol-2- yl)phenyl]carbam oylpyridines, 2, have been described. Bisoxazoline 2a was prepared in five steps from 2-nitrobenzoyl chloride in an overall yield of 71%. In contrast to related structures such as 1, bisoxazoline 2a exhibits a highly biased P-type helical conformation in solution and in the solid state. In the crystal lattice, 2a further assembles into a left-handed helical superstructure aligned along the crystallographic c axis. The barrier to helical interconversion, as measured by line-shape analysis of the temperature-dependent 1H NMR spectra of thiobenzyl derivative 2b, was determined to be quite low (ΔG? = 12.3 kcal/mol), indicating the presence of a highly dynamic helical chirality.