4914-12-9

Basic information

• Product Name: Phosphonic acid, [(2-nitrophenyl)methyl]-, diethyl ester
• CAS NO: 4914-12-9
• Molecular Formula: C11H16NO5P
• Molecular Weight: 273.226
• Mol File: 4914-12-9.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(2-nitrophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(2-nitrophenyl)methyl]-, diethyl ester(4914-12-9)
• EPA Substance Registry System: Phosphonic acid, [(2-nitrophenyl)methyl]-, diethyl ester(4914-12-9)

Safety Data

• Hazardous Substances Data: 4914-12-9(Hazardous Substances Data)

Upstream product

• 769907-13-3 2-nitrobenzylhydrazine 
• 122-52-1 triethyl phosphite 
• 78-40-0 triethyl phosphate 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 42467-40-3 2,2'-dinitrostilbene 
• 27980-46-7 5-(2-Nitro-benzylidene)-5H-dibenzo[a,d]cycloheptene 
• 104167-26-2 diethyl <(2-aminophenyl)methyl>phosphonate 
• 177284-52-5 diethyl α,α-difluoro-2-nitrobenzylphosphonate 
• 5697-85-8 2-(2-phenylethyl)aniline 
• 156049-40-0 (E)-1-isocyano-2-styrylbenzene 
• 375372-32-0 Diethyl [(2-isocyanophenyl)methyl]phosphonate 

Relevant articles and documents

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

Tunable photophysical properties of thiophene based chromophores: A conjoined experimental and theoretical investigation

In this paper we report the synthesis and photophysical properties of six novel thiophene derivatives (ThD) with D-π-A structure. The subject of this work is three nitrophenyls (1) BT-Th-NO2 and three benzonitriles (2) BT-Th-CN, substituted at

Aqueous Titanium Trichloride Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine

Treatment of o-nitrostyrenes with aqueous TiCl3 solution at room temperature afforded indoles through a formal reductive C(sp2)-H amination process. A range of functions such as halides (Cl, Br), carbonyl (ester, carbamate), cyano, hydroxy, and amino groups were tolerated. From β,β-disubstituted o-nitrostyrenes, 2,3-disubstituted indoles were formed by a domino reduction/cyclization/migration process. Mild conditions, simple experimental procedure, ready accessibility of the starting materials and good to excellent yields characterize the present transformation. The methodology was used as a key step in a concise synthesis of rizatriptan and a formal total synthesis of aspidospermidine. Mild and efficient treatment of o-nitrostyrenes with aqueous TiCl3 solution at room temperature afforded indoles through a formal reductive C(sp2)-Hamination process. A concise synthesis of a marketed drug (rizatriptan) and a formal total synthesis of aspidospermidine featuring this novel N-heterocyclization process are reported.