4931-01-5

Basic information

• Product Name: (5-METHYL-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: 5-METHYL-2-PYRIDYLHYDRAZINE;(5-METHYL-PYRIDIN-2-YL)-HYDRAZINE;2-HYDRAZINO-5-METHYLPYRIDINE;(5-METHYL-PYRIDIN-2-YL)-HYDRAZINE 4931-01-5;(5-Methylpyridin-2-yl)hydrazine, 6-Hydrazino-3-picoline;Pyridine, 2-hydrazinyl-5-methyl-
• CAS NO: 4931-01-5
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• Product Categories: Agro Products;Agro-Products
• Mol File: 4931-01-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 67-68oC
• Boiling Point: 241℃
• Flash Point: 99℃
• Appearance: /
• Density: 1.16
• Vapor Pressure: 0.00371mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: -86°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.85±0.70(Predicted)
• Stability: Hygroscopic, Moisture Sensitive, Temperature Sensitive
• CAS DataBase Reference: (5-METHYL-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-PYRIDIN-2-YL)-HYDRAZINE(4931-01-5)
• EPA Substance Registry System: (5-METHYL-PYRIDIN-2-YL)-HYDRAZINE(4931-01-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 4931-01-5(Hazardous Substances Data)

Usage

Chemical Properties

Orange

Uses

2-Hydrazino-5-methylpyridine is used as a herbicide

InChI:InChI=1/C6H9N3/c1-5-2-3-6(9-7)8-4-5/h2-4H,7H2,1H3,(H,8,9)

Upstream product

• 2369-19-9 2-fluoro-5-methylpyridine 
• 18368-64-4 2-chloro-5-methylpyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 

Downstream Products

• 4926-19-6 6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 1421923-78-5 C₁₉H₁₄F₆N₆O 
• 1427301-10-7 C₂₂H₁₆Cl₂F₃N₇ 
• 1431142-71-0 C₂₇H₂₄Cl₂F₃N₇O₂ 
• 4926-15-2 6-methyl-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine 

Relevant articles and documents

Tetrahydroindazole inhibitors of CDK2/cyclin complexes

Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogues 53 and 59 showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogues to a CDK2/cyclin complex is favored over binding to free CDK2. Computational analysis was used to predict a potential binding site at the CDK2/cyclin E1 interface.

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

COMPOUNDS AS RAS INHIBITORS AND USE THEREOF

A compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.