4931-18-4 Usage
Description
8-methyl-[1,2,4]triazolo[1,5-a]pyridine is a heterocyclic chemical compound with a molecular formula C7H7N3 and a molecular weight of 133.15 g/mol. It features a pyridine ring fused with a triazolopyridine ring, which endows it with unique structural and property characteristics.
Uses
Used in Pharmaceutical Industry:
8-methyl-[1,2,4]triazolo[1,5-a]pyridine is used as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs. Its unique structure allows it to be a key component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
Due to its heterocyclic nature and potential biological activity, 8-methyl-[1,2,4]triazolo[1,5-a]pyridine may also have applications as a pesticide or herbicide. Its ability to interact with biological systems makes it a candidate for use in controlling pests and unwanted plant growth.
Research Interest:
The chemical, physical, and biological properties of 8-methyl-[1,2,4]triazolo[1,5-a]pyridine continue to be of interest to researchers across various fields, as they seek to understand and harness its potential for practical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 4931-18-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,3 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4931-18:
(6*4)+(5*9)+(4*3)+(3*1)+(2*1)+(1*8)=94
94 % 10 = 4
So 4931-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3/c1-6-3-2-4-10-7(6)8-5-9-10/h2-5H,1H3
4931-18-4Relevant articles and documents
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors with a Novel Monodentate Binding Interaction
Ahmed, Saleh,Ayscough, Andrew,Barker, Greg R.,Canning, Hannah E.,Davenport, Richard,Downham, Robert,Harrison, David,Jenkins, Kerry,Kinsella, Natasha,Livermore, David G.,Wright, Susanne,Ivetac, Anthony D.,Skene, Robert,Wilkens, Steven J.,Webster, Natalie A.,Hendrick, Alan G.
, p. 5663 - 5672 (2017/07/22)
Herein we describe the identification of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme. These inhibitors were shown to possess a novel binding mode by X-ray crystallography, in which the triazolo N1 atom coordinates in a hitherto unreported monodentate interaction with the active site Fe2+ ion, while the benzonitrile group accepts a hydrogen-bonding interaction from the side chain residue of Asn315. Further optimization led to potent PHD-1 inhibitors with good physicochemical and pharmacokinetic properties.
New Synthesis of s-Triazolopyridines and s-Triazoloisoquinoline
Lin, Yang-i,Lang, S.A.
, p. 3123 - 3124 (2007/10/02)
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