4935-96-0

Basic information

• Product Name: N-PHTHALOYLGLYCINEAMIDE
• Synonyms: N-PHTHALOYLGLYCINEAMIDE
• CAS NO: 4935-96-0
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.18
• Mol File: 4935-96-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 437.3°Cat760mmHg
• Flash Point: 218.2°C
• Appearance: /
• Density: 1.448g/cm³
• Vapor Pressure: 7.58E-08mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: N-PHTHALOYLGLYCINEAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PHTHALOYLGLYCINEAMIDE(4935-96-0)
• EPA Substance Registry System: N-PHTHALOYLGLYCINEAMIDE(4935-96-0)

Safety Data

• Hazardous Substances Data: 4935-96-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8N2O3/c11-8(13)5-12-9(14)6-3-1-2-4-7(6)10(12)15/h1-4H,5H2,(H2,11,13)

Upstream product

• 85-44-9 phthalic anhydride 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 3842-20-4 N-(cyanomethyl)phthalimide 
• 23244-58-8 N-phthaloylglycine methyl ester 
• 4376-18-5 Monomethyl phthalate 
• 1668-10-6 glycinamide hydrochloride 
• 79-07-2 Chloroacetamide 
• 1074-82-4 potassium phtalimide 
• 135382-89-7 N-Carbamoylmethyl-2-(pyrrolidine-1-carbonyl)-benzamide 
• 4702-13-0 N-phthaloylglycine 
• 6780-38-7 N-phthaloylglycine chloride 

Downstream Products

• 136918-14-4 phthalimide 
• 14174-93-7 4-hydroxy-1(2H)-isoquinolone-3-carboxylic acid ethyl ester 

Relevant articles and documents

SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION

Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.

Synthesis and anticonvulsant activity of N,N-phthaloyl derivatives of central nervous system inhibitory amino acids

In order to study the influence of the length of the amino acid chain of N,N-phthaloyl-amino acid amides as analogues of the former anticonvulsant taltrimide on the seizure-antagonizing activity glycine, β-alanine and γ-aminobutyric acid (GABA) derivatives were synthesized. The corresponding taurine derivatives were also included. Generally, the glycine-derived amides showed a higher activity than the β-alanine and GABA derivatives in the maximal electroshock seizure (MES) test in mice upon intraperitoneal administration. The activity was comparable to the respective taurine derivatives. The N,N-phthaloyl-glycine amides were also active in the MES test upon oral administration to rats. No significant activity was noted in the seizure threshold test with subcutaneous pentylene-tetrazole. The ED50 of N,N-phthaloyl-glycine ethyl amide (4b) in the MES test upon intraperitoneal administration to mice was 19.1 mg/kg. On a molar basis this activity is comparable to the activity of phenytoin with little toxicity in the rotorod test. In conclusion, N,N-phthaloyl-glycine amides might represent promising antiepileptic drugs.

Efficient synthesis of primary amides using 2-mercaptopyridone-1-oxide-based uronium salts

S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium tetrafluoroborate (TOTT) and hexafluorophosphate (HOTT) are cheap and convenient reagents for the rapid and high-yielding preparation of primary amides when reacted with carboxylic acids and ammonium chloride in the presence of diisopropylethylamine. The reaction is chemoselective and undesired ammonolysis of other sensitive functional groups is not observed. (C) 2000 Elsevier Science Ltd.