494-40-6

Basic information

• Product Name: 1,2,4-trimethoxy-5-propenylbenzene
• Synonyms: 1,2,4-trimethoxy-5-propenylbenzene;CIS-ANDTRANS-ASARONE;BETA-AZARONE;1-(1-Propenyl)-2,4,5-trimethoxybenzene;1,4,5-Trimethoxy-2-(1-propenyl)benzene
• CAS NO: 494-40-6
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• EINECS: 207-788-7
• Mol File: 494-40-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 67°C
• Boiling Point: 296°C (estimate)
• Flash Point: 107.7oC
• Appearance: /
• Density: 1.1650
• Vapor Pressure: 1.01E-06mmHg at 25°C
• Refractive Index: 1.5683 (estimate)
• CAS DataBase Reference: 1,2,4-trimethoxy-5-propenylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-trimethoxy-5-propenylbenzene(494-40-6)
• EPA Substance Registry System: 1,2,4-trimethoxy-5-propenylbenzene(494-40-6)

Safety Data

• Hazardous Substances Data: 494-40-6(Hazardous Substances Data)

Usage

General Description

1,2,4-trimethoxy-5-propenylbenzene, also known as apiole, is a naturally occurring organic compound found in a variety of plants, including parsley and dill. It is a member of the phenylpropanoids, a class of compounds with a wide range of biological activities. Apiole has been used traditionally as a folk remedy for a variety of ailments, including as a diuretic, stimulant, and emmenagogue. In addition, apiole has been researched for its potential therapeutic benefits, including as an antibacterial and antifungal agent. However,

InChI:InChI=1/C18H24O3/c1-7-16(19-4)13-10-11-14(17(8-2)20-5)15(12-13)18(9-3)21-6/h7-12H,1-6H3

Upstream product

• 4460-86-0 asaraldehyde 
• 137-40-6 sodium proprionate 
• 123-62-6 propionic acid anhydride 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 6906-65-6 1-propyl-2,4,5-trimethoxybenzene 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 5353-15-1 1-allyl-2,4,5-trimethoxybenzene 

Downstream Products

• 134040-35-0 2,4,5-trimethoxy-β-methyl-β-nitrostyrene 
• 2020-90-8 2,4,5-Trimethoxyphenylacetone 
• 4460-86-0 asaraldehyde 
• 490-64-2 asaronic acid 
• 6906-65-6 1-propyl-2,4,5-trimethoxybenzene 
• 1214-72-8 1-(1,2-dibromo-propyl)-2,4,5-trimethoxy-benzene 
• 64-18-6 formic acid 
• 124-38-9 carbon dioxide 
• 144-62-7 oxalic acid 
• 64-19-7 acetic acid 
• 495-48-7 azoxybenzene 
• 1818-28-6 2',4',5'-trimethoxyacetophenone 
• 2883-98-9 α-asarone 
• 14894-67-8 4-(2,4,5-trimethoxyphenyl)but-3-en-2-one 

Relevant articles and documents

Photoacid-Enabled Synthesis of Indanes via Formal [3 + 2] Cycloaddition of Benzyl Alcohols with Olefins

An environmentally friendly and highly diastereoselective method for synthesizing indanes has been developed via a metastable-state photoacid system containing catalytic protonated merocyanine (MEH). Under visible-light irradiation, MEH yields a metastable spiro structure and liberated protons, which facilitates the formation of carbocations from benzyl alcohols, thus delivering diverse molecules in the presence of various nucleophiles. Mainly, a variety of indanes could be easily obtained from benzyl alcohols and olefins, and water is the only byproduct.