494209-39-1

Basic information

• Product Name: C₆H₁₂N₂O*(x)ClH
• CAS NO: 494209-39-1
• Mol File: 494209-39-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₆H₁₂N₂O*(x)ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₁₂N₂O*(x)ClH(494209-39-1)
• EPA Substance Registry System: C₆H₁₂N₂O*(x)ClH(494209-39-1)

Safety Data

• Hazardous Substances Data: 494209-39-1(Hazardous Substances Data)

Upstream product

• 137170-89-9 (1S,2R)-2-((tert-butoxycarbonyl)amino)cyyclopentane-1-carboxylic acid 
• 1071432-31-9 tert-butyl [(1S,2R)-2-carbamoylcyclopentyl]carbamate 
• 130981-12-3 (-)-N-(tert-butyloxycarbonyl)-cis-2-aminocyclopentanecarboxylic acid 
• 143679-80-5 (1S)-trans-2-<<(1,1-dimethylethoxy)carbonyl>amino>cyclopentanecarboxylic acid 
• 245115-25-7 (1R,2R)-2-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid 
• 136315-70-3 (±)-cis-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid 
• 136315-71-4 (±)-trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid 
• 359586-69-9 (1R,2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclopentanecarboxylic acid 
• 911287-04-2 2-(9H-fluoren-9-ylmethoxycarbonylamino)(1R,2R)cyclopentanecarboxamide 
• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 

Relevant articles and documents

The structure-activity profile of mercaptobenzamides’ anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target

Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile based on 39 mercaptobenzamide prodrug analogs exposed divergent activity/toxicity roles for the internal and terminal amides. To probe the relationship between antiviral activity and toxicity, we generated an improved computational model for the binding of mercaptobenzamide thioesters (SAMTs) to the HIV-1 NCp7 C-terminal zinc finger, revealing the presence of a second low-energy binding orientation, hitherto undisclosed. Finally, using NMR-derived thiol–thioester exchange equilibrium constants, we propose that thermodynamics plays a role in determining the antiviral activity observed in the SAR profile.

A novel preparation of 2-aminocyclopentanecarboxamides

Different syntheses of cis- and trans-2-aminocyclopentanecarboxamides were studied. A convenient and effective method was devised for the preparation of cis-2-aminocyclopentanecarboxamide derivatives starting from the readily available 6-tert-butoxycarbon