494775-35-8

Basic information

• Product Name: 1-(2,3-DIACETYL-5-TOSYL-Α-D-ARABINOFURANOSYL)-2-NITROIMIDAZOLE PRECURSOR FOR [18F]FAZA
• Synonyms: 1-(2,3-DIACETYL-5-TOSYL-Α-D-ARABINOFURANOSYL)-2-NITROIMIDAZOLE PRECURSOR FOR [18F]FAZA;1-(2,3-Diacetyl-5-tosyl-(-D-arabinofuranosyl)-2-nitroimidazole;1H-Imidazole, 1-[2,3-di-O-acetyl-5-O-[(4-methylphenyl)sulfonyl]-(-D-arabino-furanosyl]-2-nitro-;FAZA-Precursor;1H-I Midazole,1-[2,3-di-O-acetyl-5-O-[(4-Methylphenyl)sulfonyl]-alpha-D-arabino-furanosyl]-2-nitro-;1H-l midazole,1-[2,3-di-O-acetyl-5-O-[(4-methylphenyl)sulfonyl]- alpha-D-arabino-furanosyl]-2-nitro-
• CAS NO: 494775-35-8
• Molecular Formula: C19H21N3O10S
• Molecular Weight: 483.44914
• Mol File: 494775-35-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 102-103 °C(Solv: chloroform (67-66-3); isopropyl ether (108-20-3))
• Boiling Point: 679.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• PKA: -1.69±0.69(Predicted)
• CAS DataBase Reference: 1-(2,3-DIACETYL-5-TOSYL-Α-D-ARABINOFURANOSYL)-2-NITROIMIDAZOLE PRECURSOR FOR [18F]FAZA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-DIACETYL-5-TOSYL-Α-D-ARABINOFURANOSYL)-2-NITROIMIDAZOLE PRECURSOR FOR [18F]FAZA(494775-35-8)
• EPA Substance Registry System: 1-(2,3-DIACETYL-5-TOSYL-Α-D-ARABINOFURANOSYL)-2-NITROIMIDAZOLE PRECURSOR FOR [18F]FAZA(494775-35-8)

Safety Data

• Hazardous Substances Data: 494775-35-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 639079-78-0 1-β-D-[5-O-toluenesulfonyl-2-O-acetyl-arabinofuranosyl]-2-nitroimidazole 
• 98-59-9 p-toluenesulfonyl chloride 
• 220792-98-3 1-α-(2',3'-di-O-acetyl-D-arabinofuranosyl)-2-nitroimidazole 
• 67773-76-6 1-α-(2',3',5-tri-O-benzoyl-D-ribofuranosyl)-2-nitroimidazole 
• 532-20-7 D-Ribose 
• 911144-04-2 1-β-[2',3'-di-O-acetyl-5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 1332879-92-1 tri-O-acetyl-5-O-(tert-butyldiphenylsilyl)-β-D-ribofuranose 
• 911144-06-4 1-β-[2',3'-di-O-acetyl-D-ribofuranosyl]-2-nitroimidazole 
• 1332880-01-9 1-α-[2',3'-di-O-acetyl-D-ribofuranosyl]-2-nitroimidazole 
• 1332880-00-8 1-α-[2',3'-di-O-acetyl-5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 1332879-98-7 1-α-[5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 845868-93-1 1,2,3-tri-O-acetyl-5-O-t-butyldiphenylsilyl-D-arabinofuranose 

Relevant articles and documents

Preparation of nucleosides derived from 2-nitroimidazole and d -arabinose, d -ribose, and d -Galactose by the Vorbrueggen method and their conversion to potential precursors for tracers to image hypoxia

2-Nitroimidazole was silylated using hexaethyldisilazane and then reacted with 1-O-acetyl derivatives of d-arabinose, d-ribose, and d-galactose in acetonitrile at mild temperatures (-20 °C to rt), catalyzed by triethylsilyl triflate (Vorbrueggen condition

NOVEL SUBSTITUTED 2-NITROIMIDAZOLES USEFUL FOR HYPOXIC CELL THERAPY AND IMAGING

The present invention provides for substituted 2-nitroimidazoles suitable for the therapeutic treatment of hypoxic tissues, particularly for application in radiotherapy, chemosensitization and radiosensitization The present invention further provides subs