495418-34-3Relevant articles and documents
Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters
Sasaki, Shigeru,Suzuki, Tatuo,Uchiya, Toshihiro,Toyota, Shigenobu,Hirano, Akira,Tanemura, Mao,Teramoto, Hiroyoshi,Yamauchi, Takayasu,Higashiyama, Kimio
, p. 78 - 85 (2016)
We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc?=?tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hy
A new sequential defluorination route to α-fluoro-α,β-unsaturated ketones from trifluoromethyl ketones
Hata, Hiroshi,Kobayashi, Takeshi,Amii, Hideki,Uneyama, Kenji,Welch, John T.
, p. 6099 - 6102 (2007/10/03)
α-Fluoro-α,β-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to β,β-difluoroenol silyl ethers which were then coupled with
