496048-79-4

Basic information

• Product Name: (2S,4R)-4-benzoyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine
• Synonyms: (2S,4R)-4-benzoyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine
• CAS NO: 496048-79-4
• Molecular Weight: 539.566
• Mol File: 496048-79-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-benzoyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-benzoyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine(496048-79-4)
• EPA Substance Registry System: (2S,4R)-4-benzoyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine(496048-79-4)

Safety Data

• Hazardous Substances Data: 496048-79-4(Hazardous Substances Data)

Upstream product

• 474670-31-0 (2S,4R)-4-benzoyloxy-2-carbamoylmethyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 32807-28-6 Methyl 4-chloroacetoacetate 
• 496048-78-3 (2S,4R)-4-benzoyloxy-2-thiocarbamoylmethyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Downstream Products

• 496048-80-7 (2S,4R)-4-mesyloxy-2-[(4-methoxycarbonylmethylthiazol-2-yl)methyl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-92-1 (2S,4S)-2-(4-carbamoylmethylthiazol-2-yl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-93-2 (2S,4S)-2-[4-(2-hydroxyethyl)thiazol-2-ylmethyl]-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant articles and documents

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives

The synthesis of a new series of 1β-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4′-amide substituted thiazole moiety showed the most potent antibacterial activity.