49615-40-9 Usage
Description
3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione is a chemical compound that serves as an intermediate in the synthesis of Thiamine (T344185) analogues. It is characterized by its unique molecular structure, which includes a thiazole ring, a pyrimidine group, and a hydroxyethyl chain.
Uses
Used in Pharmaceutical Industry:
3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione is used as an intermediate in the synthesis of Thiamine (T344185) analogues for the development of new pharmaceutical compounds. Its unique structure allows for the creation of novel analogues with potential therapeutic applications.
Used in Research and Development:
3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione is also utilized in research and development settings to study the properties and potential applications of Thiamine analogues. Its role as an intermediate in the synthesis process makes it a valuable tool for scientists working in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 49615-40-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,6,1 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 49615-40:
(7*4)+(6*9)+(5*6)+(4*1)+(3*5)+(2*4)+(1*0)=139
139 % 10 = 9
So 49615-40-9 is a valid CAS Registry Number.
49615-40-9Relevant articles and documents
3 - [(4 - amino -5 - pyrimidinyl) methyl] -5 - (2 - hydroxy ethyl) -4 - methyl thiazole nitrate preparation method
-
Paragraph 0113, (2017/04/07)
The invention discloses a preparation method for 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate. The method comprises the following steps: contacting liquid sodium alkoxide with formamidine hydrochloride and then contacting an obtained substance with a compound represented by a formula (1) so as to obtain 4-amino-5-formylaminomethylpyrimidine; contacting 4-amino-5-formylaminomethylpyrimidine with an alkaline aqueous solution and then contacting an obtained substance with carbon disulfide and gamma-chloroacetyl propanol so as to obtain a compound represented by a formula (2); contacting an acidic aqueous solution with the compound represented by the formula (2) so as to obtain a compound represented by a formula (3); and contacting the compound represented by the formula (3) with hydrogen peroxide, then contacting an obtained substance with nitrate, carrying out neutralization with alkali and then carrying out solid-liquid separation so as to obtain 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate. With 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate prepared in the invention, accurate qualitative and quantitative analysis of demethylated thiamine can be realized.
