49637-07-2Relevant articles and documents
Synthesis and pharmacological characterization of new analogs of broxaterol
De Amici,Conti,Dallanoce,Kassi,Castellano,Stefancich,De Micheli
, p. 69 - 80 (2007/10/03)
A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.