4965-09-7 Usage
Description
1-Methyl-1,2,3,4-tetrahydroisoquinoline, also known as 1MeTIQ, is an endogenous compound with antidepressant and parkinsonism-preventing properties. It exhibits neuroprotective activity and serves as an important raw material and intermediate for pharmaceuticals, specifically for the development of revaprazan.
Uses
Used in Pharmaceutical Industry:
1-Methyl-1,2,3,4-tetrahydroisoquinoline is used as an antidepressant agent for its neuroprotective activity and ability to produce antidepressant-like effects similar to imipramine. It acts as a reversible short-acting moderate inhibitor of MAO A/B, contributing to its therapeutic potential in treating depression and related disorders.
Additionally, it is used as a parkinsonism-preventing substance, offering potential benefits in the management and prevention of Parkinson's disease.
Used as an Intermediate in Drug Development:
1-Methyl-1,2,3,4-tetrahydroisoquinoline serves as a crucial intermediate in the synthesis of revaprazan, a pharmaceutical compound with therapeutic applications. Its role in the development of new drugs highlights its importance in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 4965-09-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,6 and 5 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4965-09:
(6*4)+(5*9)+(4*6)+(3*5)+(2*0)+(1*9)=117
117 % 10 = 7
So 4965-09-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N/c1-8-10-5-3-2-4-9(10)6-7-11-8/h2-5,8,11H,6-7H2,1H3
4965-09-7Relevant articles and documents
Acceptorless dehydrogenation of nitrogen heterocycles with a versatile iridium catalyst
Wu, Jianjun,Talwar, Dinesh,Johnston, Steven,Yan, Ming,Xiao, Jianliang
supporting information, p. 6983 - 6987 (2013/07/26)
Gas up: A cyclometalated iridium complex is found to catalyze the dehydrogenation of various benzofused N-heterocycles, thus releasing H 2. Driven by as low as 0.1 mol % catalyst, the reaction affords quinolines, indoles, quinoxalines, isoquinolines, and β-carbolines in high yields. Copyright
Quinazoline deriviates for treating peptic ulcer
-
, (2008/06/13)
A quinazoline derivative represented by formula(I) or a pharmaceutically acceptable salt thereof is useful for the treatment of peptic ulcer, wherein: STR1 R1 and R2 are each hydrogen or a C1 -C4 alkyl group; R3 is hydrogen or a halogen; R4, R5, R6, R7, R8 and R9, which may be the same or different, are each hydrogen, a C1 -C4 alkyl group, a cyclopropyl group, or a C1 -C4 alkyl group substituted with a halogen; and R10 is a methoxy group.
