496788-67-1

Basic information

• Product Name: 1-benzhydryl-4-(2-chlorophenyl)-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine
• Synonyms: 1-benzhydryl-4-(2-chlorophenyl)-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine
• CAS NO: 496788-67-1
• Molecular Weight: 561.292
• Mol File: 496788-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzhydryl-4-(2-chlorophenyl)-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzhydryl-4-(2-chlorophenyl)-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine(496788-67-1)
• EPA Substance Registry System: 1-benzhydryl-4-(2-chlorophenyl)-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine(496788-67-1)

Safety Data

• Hazardous Substances Data: 496788-67-1(Hazardous Substances Data)

Upstream product

• 776-74-9 Bromodiphenylmethane 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 1034156-02-9 o-chlorophenylmagnesium chloride 
• 4124-31-6 trichloroacetic acid anhydride 
• 615-41-8 2-iodochlorobenzene 

Downstream Products

• 56820-27-0 4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine 
• 496788-77-3 1-benzhydryl-4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine 

Relevant articles and documents

Synthesis of 4-functionalized aryl-3,5-diacyl-1,4-dihydropyridines

The valuable N-unsubstituted 4-aryl-3,5-diacyl-1,4-dihydropyridines 12b-f, bearing an electron-withdrawing substituent at the benzene ring, have been synthesized by the copper-mediated addition of functionalized arylmagnesium reagents 2b-f to N-benzhydrylpyridinium salt 9, followed by acylation with trichloroacetic anhydride and the subsequent haloform reaction and N-deprotection.