49681-37-0

Basic information

• Product Name: N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide
• CAS NO: 49681-37-0
• Molecular Weight: 175.23
• Mol File: 49681-37-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide(49681-37-0)
• EPA Substance Registry System: N-(1,2,3,4-tetrahydronaphthalen-1-yl)formamide(49681-37-0)

Safety Data

• Hazardous Substances Data: 49681-37-0(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 64-18-6 formic acid 
• 2217-40-5 1,2,3,4-tetrahydronaphthalen-1-amine 
• 7677-24-9 trimethylsilyl cyanide 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 

Downstream Products

• 602262-90-8 1-isocyano-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Leuckart-Wallach Route Toward Isocyanides and Some Applications

Isocyanide-based multicomponent reactions (IMCR) are among the most important chemical reactions to efficiently generate molecular diversity and have found widespread use in industry and academia. Generally, isocyanides are synthesized in 1-2 steps starting from primary amines. Here, we provide experimental detail on an alternative approach toward formamides and, thus, isocyanides via the Leuckart-Wallach reaction in an improved variation. The resulting >50 synthesized and characterized formamides are useful starting materials for IMCR, as well as other chemistries. The advantage of using the Leuckart-Wallach pathway to formamides and isocyanides is the lower price, on average, of the starting materials, as well as their differential and complementary structural diversity, as compared to the primary amine pathway.

Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst

Metal-free catalysis: A method for the transamidation of primary amides with primary or secondary amines provides access to secondary and tertiary amides, by utilizing catalytic quantities of hydroxylamine hydrochloride to activate the chemically robust primary amide group (see scheme). A mechanism of primary amide activation through a hydrogen-bonding complex is proposed. Copyright

1-Benzoyl-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)-urea, a novel and useful intermediate for the preparation of animal growth promoting agents

This invention relates to 1-benzoyl (and 1-substituted benzoyl)-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)ureas, novel and useful intermediates for the preparation of 1,2,3,4-tetrahydro-4-oxo-1-naphthylurea and certain derivatives thereof. The above tetrahydro-4-oxo-1-naphthyl-urea and certain derivatives thereof are animal growth promoting agents. This invention further relates to methods of preparation of said 1-benzoyl (and 1-substituted benzoyl) 3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)ureas.