496848-50-1

Basic information

• Product Name: Toluene-4-sulfonic acid (1R,2R,4aS,5R,8aS)-2-hydroxy-1,4a-dimethyl-6-methylene-5-[2-(2-oxo-tetrahydro-furan-3-yl)-ethyl]-decahydro-naphthalen-1-ylmethyl ester
• CAS NO: 496848-50-1
• Molecular Weight: 490.661
• Mol File: 496848-50-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (1R,2R,4aS,5R,8aS)-2-hydroxy-1,4a-dimethyl-6-methylene-5-[2-(2-oxo-tetrahydro-furan-3-yl)-ethyl]-decahydro-naphthalen-1-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (1R,2R,4aS,5R,8aS)-2-hydroxy-1,4a-dimethyl-6-methylene-5-[2-(2-oxo-tetrahydro-furan-3-yl)-ethyl]-decahydro-naphthalen-1-ylmethyl ester(496848-50-1)
• EPA Substance Registry System: Toluene-4-sulfonic acid (1R,2R,4aS,5R,8aS)-2-hydroxy-1,4a-dimethyl-6-methylene-5-[2-(2-oxo-tetrahydro-furan-3-yl)-ethyl]-decahydro-naphthalen-1-ylmethyl ester(496848-50-1)

Safety Data

• Hazardous Substances Data: 496848-50-1(Hazardous Substances Data)

Upstream product

• 142037-79-4 andrographolide 
• 98-59-9 p-toluenesulfonyl chloride 
• 496848-46-5 3-[2-((1R,4aS,5R,6R,8aS)-6-Hydroxy-5-hydroxymethyl-5,8a-dimethyl-2-methylene-decahydro-naphthalen-1-yl)-ethyl]-dihydro-furan-2-one 

Relevant articles and documents

Chemical transformation of andrographolide

Tosylation of andrographolide 1, with p-TsCl pyridine furnishes compounds 3 and 4. The reaction of 1 with in situ generated nickel boride yields compounds 6 and 8. Monotosylation of 6 followed by reaction with NaI refluxing in acetone furnishes the iodide 13. But all attempts to generate an oxetane moiety in 13 corresponding to compund 2 failed.