496854-94-5

Basic information

• Product Name: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-6-chloro-4-(4-chlorophenyl)-
• CAS NO: 496854-94-5
• Molecular Formula: C20H12Cl2N2O
• Molecular Weight: 367.234
• Mol File: 496854-94-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-6-chloro-4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-6-chloro-4-(4-chlorophenyl)-(496854-94-5)
• EPA Substance Registry System: 4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-6-chloro-4-(4-chlorophenyl)-(496854-94-5)

Safety Data

• Hazardous Substances Data: 496854-94-5(Hazardous Substances Data)

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 604-44-4 4-chloronaphthalen-1-ol 

Downstream Products

• 496854-97-8 N-[6-chloro-4-(4-chloro-phenyl)-3-cyano-4H-benzo[h]chromen-2-yl]-acetamide 
• 496855-09-5 N-[6-chloro-4-(4-chloro-phenyl)-3-cyano-4H-benzo[h]chromen-2-yl]-formimidic acid ethyl ester 
• 496855-18-6 N-[6-chloro-4-(4-chloro-phenyl)-3-cyano-4H-benzo[h]chromen-2-yl]-formamidine 
• 496855-03-9 6-Chloro-4-(4-chloro-phenyl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-4H-benzo[h]chromene-3-carbonitrile 

Relevant articles and documents

Synthesis, antitumor activity of 2-amino-4H-benzo[h]chromene derivatives, and structure-activity relationships of the 3- and 4-positions

Several 2-amino-4H-benzo[h]chromenes (3a-i) and (5a-h) were obtained by reaction of 4-chloro-1-naphthol (1) with α-cyanocinnamonitrile (2a-i) or ethyl α-cyanocinnamate derivatives (4a-h), respectively. Structures of these compounds were established on the

Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.

The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported. The key intermediate 3-amino-9-chloro-1-(4-halophenyl)-1H-benzo[h]chromene-2-carbonitrile (3) was obtained by treating 4-halobenzylidenmalononitriles (1a-c) and ethyl 4-halobenzylidenmalonates (1d-f) with 4-chloro-1-naphthol (2) in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesized compounds.