496863-48-0

Basic information

• Product Name: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)
• Synonyms: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI);1-[2-(Methylthio)-4-pyrimidinyl]ethanone;1-(2-(Methylthio)pyrimidin-4-yl)ethanone;1-[2-(Methylsulfanyl)-4-pyrimidinyl]-1-ethanone;4-Acetyl-2-methylthiopyrimidine;1-(2-Methylsulfanyl-pyriMidin-4-yl)-ethanone;1-[2-(Methylsulfanyl)pyriMidin-4-yl]ethan-1-one;1-[2-(Methylsulfanyl)pyriMidin-4-yl]-1-ethanone
• CAS NO: 496863-48-0
• Molecular Formula: C₇H₈N₂OS
• Molecular Weight: 168.21622
• EINECS: 200-589-5
• Product Categories: ACETYLGROUP
• Mol File: 496863-48-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 301℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.23
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.05±0.20(Predicted)
• CAS DataBase Reference: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(496863-48-0)
• EPA Substance Registry System: Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI)(496863-48-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 496863-48-0(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI) is a chemical compound with a molecular formula C8H8N2O2S. It is a derivative of pyrimidine and contains a methylthio group. Ethanone, 1-[2-(methylthio)-4-pyrimidinyl]- (9CI) has potential applications in pharmaceuticals and agrochemicals due to its structural characteristics and reactivity. It is important to handle this chemical with care, as it may pose a risk to human health and the environment if not properly managed. Further research and testing may be needed to fully understand the properties and potential uses of this compound.

InChI:InChI=1/C7H8N2OS/c1-5(10)6-3-4-8-7(9-6)11-2/h3-4H,1-2H3

Upstream product

• 521092-35-3 4-(1,1-dimethoxy-ethyl)-2-methylsulfanyl-pyrimidine 
• 521092-40-0 4-(1-ethoxyvinyl)-2-methylsulfanylpyrimidine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 17356-08-0 thiourea 
• 74-88-4 methyl iodide 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 106157-94-2 1-(dimethylamino)-4,4-dimethoxypent-1-en-3-one 

Downstream Products

• 521092-07-9 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-64-8 C₁₇H₂₁N₃O₄S 
• 521091-13-4 C₁₆H₁₆FN₅O 
• 521087-88-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-isopropoxypyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-46-6 1-(2-methylsulfanylpyrimidin-4-yl)ethanoneoxime tosylate 
• 521092-16-0 1-(4-fluorophenyl)-5-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-71-7 C₁₆H₁₉FN₄O₃S 
• 521092-72-8 C₁₆H₁₉FN₄O₅S 
• 521092-13-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 1453847-79-4 1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-84-0 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-82-8 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1453852-80-6 1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyrimidin-2(1H)-one 
• 1403332-60-4 N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide 

Relevant articles and documents

AMINOPYRIMIDINE COMPOUND USED FOR INHIBITING ACTIVITY OF PROTEIN KINASE

The present invention relates to an aminopyrimidine compound having an inhibitory effect on the activity of protein kinase as well as the preparation and use thereof. Specifically, disclosed by the present invention is an aminopyrimidine compound represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate or hydrate thereof, as well as a pharmaceutical composition comprising said compound and a use method therefor. The method comprises a method for treating cell proliferative diseases and conditions such as cancer and immune diseases.

PROCESS FOR PRODUCTION OF 4-ACETYLPYRIMIDINES AND CRYSTALS THEREOF

Compound (II) is reacted with formate in the presence of an alkali metal alkoxide and the like to give compound (III); then this is reacted with compound (IVa) or compound (IVb) to give compound (V); then this is reacted with compound (VI) to give compoun