49701-11-3

Basic information

• Product Name: 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE
• Synonyms: 8-Chloro-4-chromanone;8-CHLOROCHROMAN-4-ONE;5-((1-(2-Chlorobenzyl)-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione;8-Chloro-4-chroManone 97%;8-CHLORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-ONE;8-chloro-2,3-dihydrochroMen-4-one
• CAS NO: 49701-11-3
• Molecular Formula: C₉H₇ClO₂
• Molecular Weight: 182.60368
• EINECS: 1312995-182-4
• Mol File: 49701-11-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 321.8 °C at 760 mmHg
• Flash Point: 149.6 °C
• Appearance: /
• Density: 1.345 g/cm³
• Vapor Pressure: 0.000291mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE(49701-11-3)
• EPA Substance Registry System: 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE(49701-11-3)

Safety Data

• Hazardous Substances Data: 49701-11-3(Hazardous Substances Data)

Usage

General Description

8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE is a chemical compound with the molecular formula C10H7ClO2. It is a chromenone derivative with a chlorine atom attached to the eighth carbon position. 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE is commonly used in medicinal and pharmaceutical research due to its potential biological activities and pharmacological properties. It has been found to exhibit anti-inflammatory, antioxidant, and anticancer properties, making it a valuable candidate for the development of new drugs and treatments. Additionally, its unique structure and reactivity make it a versatile building block for synthesizing other organic compounds. Overall, 8-CHLORO-2,3-DIHYDRO-4H-CHROMEN-4-ONE shows promise as a key player in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C9H7ClO2/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3H,4-5H2

Upstream product

• 7170-45-8 3-(2-chlorophenoxy)propionic acid 
• 117543-39-2 4,8-dichlorochromene 
• 117543-27-8 1-Chloro-2-(3-chloro-prop-2-ynyloxy)-benzene 
• 46055-17-8 3-(2-chloro-phenoxy)-propionitrile 
• 1181446-74-1 C₉H₈Cl₂O₂ 
• 95-57-8 2-monochlorophenol 
• 17061-92-6 3-(2-chlorophenoxy)-1-propyne 

Downstream Products

• 1311409-28-5 C₄₃H₅₂FN₅O₇ 
• 1311411-84-3 C₃₃H₃₈BrFN₂O₆ 
• 1311411-86-5 C₄₀H₄₇FN₄O₆ 
• 1311411-88-7 C₃₅H₃₉FN₄O₄ 
• 1311412-12-0 C₄₀H₅₅BrN₂O₇Si 
• 1311412-15-3 C₃₄H₄₁BrN₂O₇ 
• 1311412-61-9 C₁₈H₁₈ClNO₃ 
• 1311412-62-0 C₂₁H₂₂ClNO₃ 
• 1311412-63-1 C₃₆H₄₂BrClN₂O₆ 
• 1311412-68-6 C₃₆H₄₁BrCl₂N₂O₆ 
• 112685-48-0 3-benzylaminomethyl-8-chloro-chroman-4-one 

Relevant articles and documents

Synthesis of a P-Glycoprotein Inhibitor and Its High-Energy (Z)-Isomer by Carbenoid Eliminative Cross-Coupling

To gauge the feasibility of carbenoid eliminative cross-coupling for the synthesis of polyfunctional alkenes, a P-glycoprotein inhibitor containing an (E)-configured 4-chromanylidene-type trisubstituted olefin was prepared as well as its previously undescribed (Z)-isomer. Stereospecific alkene synthesis required generation of functionalized enantioenriched α-metalated carbamates [R1R2CM(O2CNi-Pr2), M = Li or Bneo], and problems associated with incorrect lithiation regioselectivity and unexpected organolithium configurational lability were encountered. Solutions to these difficulties are described together with a method for ee determination of α-carbamoyloxyboronates.

5-AMINO- 4-HYDROXYPENTOYL AMIDES

HIV inhibitors of formula (I) wherein R1 is halo, C1-4alkoxy, trifluoromethoxy; R2 is a group of formula (A); R3 is a group of formula (B); R4 is a group of formula (C); n is 0 or 1; A is CH or N; R5 and R6 are hydrogen, C1-4alkyl, halo; R7 and R8 are C1-4alkyl or C1-4alkoxyC1-4alkyl; R9 is C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; R10 is hydrogen, C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.

A SIMPLE ROUTE FOR THE SYNTHESIS OF 4-CHLOROCHROMENES AND CHROMAN-4-ONES

A one pot synthesis of a number of 4-chlorochromenes and chroman-4-ones was achived from γ-chloropropargyl aryl ethers proceeding through Claisen rearrangement, depending upon the solvent of choice.