49706-30-1

Basic information

• Product Name: Z-THR-NHNH2
• Synonyms: N-ALPHA-CARBOBENZOXY-L-THREONINE HYDRAZIDE;Z-THREONINE-NHNH2;Z-THR-NHNH2;Z-L-THREONINE HYDRAZIDE;Cbz-L-Threoninehydrazide;benzyl (2S,3R)-1-hydrazinyl-3-hydroxy-1-oxobutan-2-ylcarbamate;Z-L-threonine hydrazide≥ 98% (HPLC);Z-L-Thr-NHNH2
• CAS NO: 49706-30-1
• Molecular Formula: C₁₂H₁₇N₃O₄
• Molecular Weight: 267.28
• Mol File: 49706-30-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Refractive Index: 1.529
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-THR-NHNH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-THR-NHNH2(49706-30-1)
• EPA Substance Registry System: Z-THR-NHNH2(49706-30-1)

Safety Data

• Hazardous Substances Data: 49706-30-1(Hazardous Substances Data)

Usage

General Description

Z-THR-NHNH2, also known as Z-threoninol, is a chemical compound used in the field of organic chemistry, specifically in peptide synthesis. It is known for its role as a protecting group for amino acids during peptide synthesis, which helps prevent unwanted reactions in certain parts of the molecule. Its molecular formula is C11H16N2O5 and it comes as a colorless to slightly yellow crystal or powder. Z-THR-NHNH2 requires proper handling and storage due to its potential health hazards.

InChI:InChI=1/C4H11N3O2/c1-2(8)3(5)4(9)7-6/h2-3,8H,5-6H2,1H3,(H,7,9)/t2?,3-/m0/s1

Upstream product

• 501-53-1 benzyl chloroformate 
• 57224-63-2 methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate 

Downstream Products

• 19649-01-5 Z-Thr-Phe-OMe 
• 49705-87-5 Z-Thr-Gly-Boc Hydrazid 
• 7705-83-1 (5t-methyl-2-oxo-oxazolidin-4r-yl)-carbamic acid benzyl ester 
• 78141-50-1 Z-Thr-Pro-Ile-Leu-Pro-Gln-OtBu 
• 41446-42-8 Z-Thr-N₃ 
• 49705-86-4 N-benzyloxycarbonyl-L-threonyl-glycine 

Relevant articles and documents

Process for preparing optically active oxazolidinone derivative

Disclosed is a process for preparing an optically active oxazolidinone derivative comprising allowing hydrazine to react on an optically active ester having a hydroxyl group at the 3-position which is represented by formula (II): wherein R1represents a lower alkyl group having 1 to 4 carbon atoms, a phenyl group, a methoxymethyl group, a benzyloxymethyl group, a benzyloxycarbonylaminomethyl group which may have a substituent or substituents on the benzene ring thereof, an acylaminomethyl group having 3 to 10 carbon atoms, or an alkyloxycarbonylaminomethyl group having 3 to 6 carbon atoms; R2and R3, which may be the same or different, each represent a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, a phenyl group, an acetylaminomethyl group, a benzoylaminomethyl group, or a benzyl group; and * indicates an asymmetric carbon atom, and subjecting the resulting hydrazide to Curtius rearrangement.