49739-37-9

Basic information

• Product Name: 1,2,5-Oxadiazole, 3-methyl-4-(phenylthio)-, 5-oxide
• CAS NO: 49739-37-9
• Molecular Formula: C9H8N2O2S
• Molecular Weight: 208.241
• Mol File: 49739-37-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,5-Oxadiazole, 3-methyl-4-(phenylthio)-, 5-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole, 3-methyl-4-(phenylthio)-, 5-oxide(49739-37-9)
• EPA Substance Registry System: 1,2,5-Oxadiazole, 3-methyl-4-(phenylthio)-, 5-oxide(49739-37-9)

Safety Data

• Hazardous Substances Data: 49739-37-9(Hazardous Substances Data)

Usage

Chemical class

Oxadiazole class of compounds

Molecular structure

Heterocyclic organic compound with a five-membered oxadiazole ring and a thioether functional group

Potential applications

Pharmaceuticals and agrochemicals due to its biological activities

Physical properties

Useful building block for the synthesis of various other organic compounds

Safety concerns

Potential health and environmental hazards, should be handled with care

Research interest

Diverse potential applications and properties make it an interesting subject of study for researchers in the field of organic chemistry

Upstream product

• 108-98-5 thiophenol 
• 142764-04-3 N-Hydroxy-2-[(E)-hydroxyimino]-thiopropionimidic acid phenyl ester 
• 65514-04-7 3-chloro-4-methylfuroxan 
• 49739-36-8 3-methyl-4-(phenylthio)furoxan 

Downstream Products

• 98384-64-6 (3aS,3cS,6aR,8aR)-3b-Methyl-2,5-diphenyl-tetrahydro-7,8-dioxa-2,5,7a-triaza-dicyclopenta[a,f]pentalene-1,3,4,6-tetraone 
• 49739-36-8 3-methyl-4-(phenylthio)furoxan 
• 145409-25-2 4-methyl-3-(phenylsulfinyl)furoxan 
• 49739-43-7 4-methyl-3-(phenylsulfonyl)furoxan 

Relevant articles and documents

Pharmacochemistry of the furoxan ring: Recent developments

In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.

Unsymmetrically Substituted Furoxans. VIII (1). Chloromethylfuroxans

The two isomeric chloromethylfuroxans have been prepared.Their structures, thermal equilibration and reaction toward thiophenoxide ion are discussed.Kinetics of the 4-methyl--> 3-methyl isomer thermal conversion are also reported.