4976-05-0

Basic information

• Product Name: N-[2-(pyridin-2-yl)ethyl]benzamide
• CAS NO: 4976-05-0
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.2738
• Mol File: 4976-05-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 452.4°C at 760 mmHg
• Flash Point: 227.4°C
• Density: 1.13g/cm³
• Vapor Pressure: 2.25E-08mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: N-[2-(pyridin-2-yl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(pyridin-2-yl)ethyl]benzamide(4976-05-0)
• EPA Substance Registry System: N-[2-(pyridin-2-yl)ethyl]benzamide(4976-05-0)

Safety Data

• Hazardous Substances Data: 4976-05-0(Hazardous Substances Data)

Usage

General Description

N-[2-(pyridin-2-yl)ethyl]benzamide, also known as 2-(Benzamido)ethylpyridine, is a chemical compound with the molecular formula C15H14N2O. It is a benzamide derivative that contains a pyridine and an ethyl group. N-[2-(pyridin-2-yl)ethyl]benzamide is commonly used in the field of organic chemistry and pharmaceutical research as a building block for the synthesis of various biologically active molecules. The presence of the pyridine moiety in this compound makes it a potential ligand for metal complexes, and it has been studied for its potential applications in catalysis and material science. Additionally, it may also have potential pharmacological properties that could be investigated for drug development purposes.

Upstream product

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Relevant articles and documents

Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

Green synthesis of benzamides in solvent- and activation-free conditions

Herein, we describe a clean and ecocompatible pathway for both N-benzoylation and N-acetylation of anilines, amines, diamines, and aminoalcohols using three enol esters with good yields. We have improved the use of vinyl benzoate for the direct introduction of a benzamido-moiety under solvent- and activation-free conditions. The recovered amides are easily isolated by crystallization. Copyright

Direct Coupling between β-Functionalized Organolithium Compounds and Aryl and Vinyl Halides

Treatment of N-lithio-N-(2-lithioethyl)benzamide with different aromatic and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 3-10.