497865-81-3

Basic information

• Product Name: (R)-2-bromo-3-phenylpropionic acid D-phenylalaninamide salt
• Synonyms: (R)-2-bromo-3-phenylpropionic acid D-phenylalaninamide salt
• CAS NO: 497865-81-3
• Molecular Weight: 393.28
• Mol File: 497865-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-bromo-3-phenylpropionic acid D-phenylalaninamide salt(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-bromo-3-phenylpropionic acid D-phenylalaninamide salt(497865-81-3)
• EPA Substance Registry System: (R)-2-bromo-3-phenylpropionic acid D-phenylalaninamide salt(497865-81-3)

Safety Data

• Hazardous Substances Data: 497865-81-3(Hazardous Substances Data)

Upstream product

• 35016-63-8 (S)-2-bromo-3-phenylpropionic acid 
• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 
• 5241-58-7 D-Phenylalaninamide 

Downstream Products

• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 

Relevant articles and documents

PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-SUBSTITUTED CARBOXYLIC ACID

The present invention relates to a process for efficiently producing an optically active 2-bromocarboxylic acid and an optically active 2-sulfonyloxycarboxylic acid, which are important in the production of medicinal compounds and so forth. An optically active 2-sulfonyloxycarboxylic acid ester is subjected to deprotection under acid conditions to obtain an optically active 2-sulfonyloxycarboxylic acid. A metal bromide is caused to act on the acid to brominate it with configuration inversion at position 2 to thereby produce an optically active 2-bromocarboxylic acid. The resultant optically active 2-bromocarboxylic acid is isolated/purified by subjecting it to a step in which the acid is crystallized and separated as a salt with a base. Thus, an optically active 2-bromocarboxylic acid having a high chemical purity and high optical purity can be produced.