49845-16-1Relevant articles and documents
Process for making pyrazines from 2-aza-1,3-butadienes
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, (2008/06/13)
Process for the preparation of an amino-pyrazine falling within the formula: SPC1 In which R1 and R2 each represent a hydrogen atom, or an alkyl or aryl group, or together with the carbon atoms of the pyrazine ring form a cyclic hydrocarbon having 5 to 7 carbon atoms, and X represents a cyano, carboxy, carbonamido, alkoxy-carbonyl or aryloxycarbonyl group which comprises subjecting a 2-aza-1,3-butadiene of the general formula: EQU1 wherein Z and Zi each represent an alkyl group or together with the nitrogen atom form a heterocyclic compound possibly containing another hetero atom to the action of ammonia and reacting the 4-amino-2-aza-1,3-butadiene of formula EQU2 thus obtained with a basic agent: novel compounds of formula VIII in which R1 and R2 each represent a different alkyl or aryl group or together with the carbon atoms of the pyrazine ring form a cyclic hydrocarbon containing 5 to 7 carbon atoms: intermediate compounds of formula: EQU3 wherein X, R1 and R2 have the meanings given above and Z and Z' each represent an alkyl group or together with the nitrogen atom form a heterocyclic compound possibly containing another hetero-atom; and intermediate compounds of the formula: EQU4 wherein X, R1 and R2 have the meanings given above.
