50-39-5 Usage
Description
Protheobromine, also known as 1-(2-Hydroxypropyl)theobromine, is a xanthine derivative that acts as an antagonist at both A1 and A2 adenosine receptors. It is a compound with potential applications in various fields due to its unique properties and interactions with adenosine receptors.
Uses
Used in Pharmaceutical Industry:
Protheobromine is used as a pharmaceutical agent for its antagonistic effects on A1 and A2 adenosine receptors. This property makes it a potential candidate for the development of drugs targeting conditions related to adenosine receptor activity, such as asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders.
Additionally, due to its antagonistic effects on adenosine receptors, protheobromine may also have potential applications in the treatment of neurological disorders, cardiovascular conditions, and even certain types of cancer, where adenosine receptor modulation can play a role in disease progression and treatment response.
Check Digit Verification of cas no
The CAS Registry Mumber 50-39-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 50-39:
(4*5)+(3*0)+(2*3)+(1*9)=35
35 % 10 = 5
So 50-39-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N4O3/c1-6(15)4-14-9(16)7-8(11-5-12(7)2)13(3)10(14)17/h5-6,15H,4H2,1-3H3
50-39-5Relevant articles and documents
Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues
Cavallaro, Rosaria A.,Filocamo, Luigi,Galuppi, Annamaria,Galione, Antony,Brufani, Mario,Genazzani, Armando A.
, p. 2527 - 2534 (2007/10/03)
Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.