5002-07-3Relevant articles and documents
Iminophosphine-palladium(0) complexes as highly active catalysts in the Suzuki reaction. Synthesis of undecaaryl substituted corroles
Scrivanti, Alberto,Beghetto, Valentina,Matteoli, Ugo,Antonaroli, Simonetta,Marini, Alessia,Mandoj, Federica,Paolesse, Roberto,Crociani, Bruno
, p. 5861 - 5864 (2004)
The iminophosphine-palladium(0) complex [Pd(dmfu)(P-N)] [dmfu=dimethyl fumarate; P-N=2-(PPh2)C6H4-1-CH=NC 6H4-4-OMe] is a very efficient catalyst for the Suzuki coupling. In the reaction of aryl bromides with phenylboronic acid, turnover numbers up to ca. 200,000 are obtained at 110°C in 2h. Good rates are obtained also with the sterically hindered and electronically deactivated 2-bromo-1,3,5-trimethylbenzene. The complex is able to catalyze the exhaustive arylation of 2,3,7,8,12,13,17,18-octabromo-5,10,15-triphenylcorroleCu(III) to yield the corresponding undecaaryl substituted derivative.
Synthesis and biological evaluation of 3,5-substituted pyrazoles as possible antibacterial agents
Asmara, Anjar P.,Bottomley, Amy L.,Harry, Elizabeth J.,Och, Anthony,Payne, Matthew,Ung, Alison T.
, (2021/09/24)
The emergence of multi-drug resistant bacteria has increased the need for novel antibiotics to help overcome what may be considered the greatest threat to modern medicine. Here we report the synthesis of fifteen novel 3,5-diaryl-1H- pyrazoles obtained via
A one-pot protocol for the fluorosulfonation and Suzuki coupling of phenols and bromophenols, streamlined access to biaryls and terphenyls
Hu, Rui,Li, Xinmin,Ren, Changyue,Yuan, Zeli,Zhang, Hang,Zhang, Tingting
supporting information, p. 4748 - 4753 (2020/08/17)
A one-pot protocol for the fluorosulfation and Suzuki coupling of phenols is described. The tandem reaction proceeds efficiently at room temperature, and various biaryls and biaryl fluorosulfates were obtained in good to excellent yields. Furthermore, biaryl fluorosulfates were utilized as versatile building blocks for the preparation of terphenyls. The Royal Society of Chemistry 2020.
Efficient construction of C–C bonds from aryl halides/aryl esters with arylboronic acids catalysed by palladium(II) thiourea complexes
Thimma Sambamoorthy, Manikandan,Rengan, Ramesh,Jan Grzegorz, Malecki
, (2019/11/03)
A new set of palladium(II) complexes comprising phenyl(thiazolyl)thiourea ligands have been successfully synthesized and characterized with the aid of analytical as well as spectral (IR, UV–visible and NMR) methods. A distorted square-planar geometry with N^S coordination mode of thiourea ligands in the new palladium complexes was corroborated by single-crystal X-ray diffraction methods. Interestingly, the palladium(II) thiourea complexes showed the highest catalytic activity with 0.1 mol% catalyst loading in Suzuki–Miyaura cross-coupling reactions utilizing a range of aryl bromides/unactivated aryl chlorides with arylboronic acids as coupling partners in aqueous–organic media. Syntheses of diaryl ketones using aryl esters and arylboronic acids as coupling partners were also achieved with low catalyst loading within 20 h. The potential of our catalyst was demonstrated by its wide substrate scope, low catalyst loadings and high isolated yield. Moreover, the influences of key parameters like solvent, base, temperature and catalyst loading were also investigated.