5002-38-0

Basic information

• Product Name: (3'-FLUORO-BIPHENYL-4-YL)-ACETIC ACID
• Synonyms: AKOS BAR-2300;4-BIPHENYL-3'-FLUORO-ACETIC ACID;(3'-FLUORO-BIPHENYL-4-YL)-ACETIC ACID;4-(3-Fluorophenyl)phenylacetic acid
• CAS NO: 5002-38-0
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.23
• Mol File: 5002-38-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 390.7 °C at 760 mmHg
• Flash Point: 190.1 °C
• Appearance: /
• Density: 1.235 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3'-FLUORO-BIPHENYL-4-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (3'-FLUORO-BIPHENYL-4-YL)-ACETIC ACID(5002-38-0)
• EPA Substance Registry System: (3'-FLUORO-BIPHENYL-4-YL)-ACETIC ACID(5002-38-0)

Safety Data

• Hazardous Substances Data: 5002-38-0(Hazardous Substances Data)

Usage

General Description

(3'-Fluoro-biphenyl-4-yl)-acetic acid is a chemical compound that belongs to the class of biphenyl-4-yl-acetic acids and contains a fluoro substituent at the 3' position. It is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. (3'-Fluoro-biphenyl-4-yl)-acetic acid has been studied for its potential anti-inflammatory and analgesic properties, and its derivatives have shown promise in the development of new drugs for the treatment of pain and inflammatory conditions. Additionally, it has also been investigated for its potential use in the synthesis of liquid crystals and materials for organic electronic devices. Overall, (3'-Fluoro-biphenyl-4-yl)-acetic acid holds potential for various applications in the fields of medicine, materials science, and organic chemistry.

Upstream product

• 67-56-1 methanol 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 508229-65-0 2-(3'-Fluoro-biphenyl-4-yl)-N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl)-acetamide 
• 348087-31-0 2-(3′-fluoro-[1,1′-biphenyl]-4-yl)-N-methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide 

Relevant articles and documents

THIAZOLOPIPERAZINE DERIVATIVES AND COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES COMPRISING THE SAME

The present invention provides a thiazolopiperazine derivative, and a pharmaceutical composition and a health functional food composition for preventing or treating autoimmune diseases containing the same as an active component. A compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof according to the present invention can have an effect of inhibiting lysophosphatidic acid 1 (LPA1) receptor activation, thereby being able to be usefully used as the pharmaceutical composition or the health functional food composition for preventing or treating LPA1-related diseases. In addition, it is possible to effectively prevent or treat not only autoimmune diseases, but also other immune-related diseases with similar mechanisms of occurrence by using the pharmaceutical composition and the health functional food composition.COPYRIGHT KIPO 2020

Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis

Aryl zinc bromides undergo palladium catalyzed coupling reactions to aryl bromides which are bound to a polystyrene resin via an ester linkage. Liberation of the biaryl carboxylic ester was achieved by transesterification.