500214-47-1

Basic information

• Product Name: Benzamide, N-[2-(dimethylamino)-1-methylethyl]-N-1,3-dioxolo[4,5-g]quinolin-8-yl-2- iodo-4,5-dimethoxy-
• CAS NO: 500214-47-1
• Molecular Formula: C24H26IN3O5
• Molecular Weight: 563.392
• Mol File: 500214-47-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[2-(dimethylamino)-1-methylethyl]-N-1,3-dioxolo[4,5-g]quinolin-8-yl-2- iodo-4,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[2-(dimethylamino)-1-methylethyl]-N-1,3-dioxolo[4,5-g]quinolin-8-yl-2- iodo-4,5-dimethoxy-(500214-47-1)
• EPA Substance Registry System: Benzamide, N-[2-(dimethylamino)-1-methylethyl]-N-1,3-dioxolo[4,5-g]quinolin-8-yl-2- iodo-4,5-dimethoxy-(500214-47-1)

Safety Data

• Hazardous Substances Data: 500214-47-1(Hazardous Substances Data)

Upstream product

• 108-15-6 1-(dimethylamino)-2-propylamine 
• 35478-79-6 4-hydroxy-6,7-methylenedioxyquinoline 
• 59134-89-3 8-chloro-2H-[1,3]dioxolo[4,5-g]quinoline 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 113258-92-7 4,5-dimethoxy-2-iodobenzoyl chloride 
• 500214-40-4 N'-(6,7-methylenedioxyquinolin-4-yl)-N,N-dimethylpropane-1,2-diamine 

Relevant articles and documents

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.

Several 5,12-diazachrysen-6-ones and 5,6,11-triazachrysen-12-ones were synthesized with varied substituents at the 5- or 11-position, respectively. Each compound was evaluated for its potential to stabilize the cleavable complex formed with TOP1 and DNA.

METHODS FOR TREATING GASTRIC AND PANCREATIC MALIGNANCIES

The invention provides methods and pharmaceutical compositions for treating pancreatic cancer or gastric cancer or a metastasis thereof.