5004-46-6

Basic information

• Product Name: 1-Methylphthalazine
• Synonyms: 1-Methylphthalazine
• CAS NO: 5004-46-6
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Mol File: 5004-46-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methylphthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylphthalazine(5004-46-6)
• EPA Substance Registry System: 1-Methylphthalazine(5004-46-6)

Safety Data

• Hazardous Substances Data: 5004-46-6(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic aromatic compound It has a ring structure containing a nitrogen atom, making it different from purely carbon-based aromatic compounds.

Structure

Six-membered ring with a nitrogen atom The nitrogen atom is integrated into the ring, contributing to its unique properties.

Usage

Synthesis of pharmaceuticals and organic compounds 1-Methylphthalazine serves as a precursor in various chemical reactions, making it a valuable building block in the creation of drugs and other organic molecules.

Potential applications

Organic electronic materials The compound may have uses in the development of electronic devices based on organic materials, due to its electronic properties.

Potential applications

Dye and pigment intermediate 1-Methylphthalazine can be used as an intermediate in the production of dyes and pigments for various industries.

Physical appearance

Colorless to light yellow liquid The compound is a liquid with a very faint color, making it visually unobtrusive.

Stability

Relatively stable under normal conditions The compound does not readily react or break down, making it suitable for various industrial processes and storage.

Upstream product

• 19064-68-7 1-chloro-4-methylphthalazine 
• 24953-65-9 phthalazin-1-yl-malononitrile 
• 24953-64-8 phthalazin-1-yl-malonic acid diethyl ester 
• 77972-45-3 2,4-dimethylphthalazinium iodide 
• 959773-66-1 1-iodo-4-methylphthalazine 
• 10034-85-2 hydrogen iodide 
• 21452-55-1 1-cyano-1H-phthalazine-2-carboxylic acid diethylamide 
• 5784-45-2 1-chlorophthalazine 
• 253-52-1 PHTHALAZINE 
• 67-56-1 methanol 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 26641-29-2 4-isopropylidene-1,1,7-trimethyl-1,11b-dihydro-[1,3]oxazino[4,3-a]phthalazin-2-one 
• 75208-08-1 1-cyano-2-benzoyl-4-methyl-1,2-dihydrophthalazine 
• 127797-12-0 1-Methylisoindol 
• 75218-33-6 1-cyano-1,4-dimethyl-2-benzoyl-1,2-dihydrophthalazine 

Relevant articles and documents

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Phosphoramidates as Transient Precursors of Nitrogen-Centered Radical Under Visible-Light Irradiation: Application to the Synthesis of Phthalazine Derivatives

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C?N bond formation. (Figure presented.).

Nature of Reissert Analogs Derived from N,N-Dialkyl and N,N-Diaryl Carbamoyl Chlorides

Reissert analogs were prepared from the reaction of isoquinoline and phthalazine with carbamoyl chlorides and cyanide using the methylene chloride-water method.Alkylation, condensation, Michael addition, and hydrolysis reactions of these Reissert analogs have been studied and found in many cases, to be similar to those of the isoquinoline Reissert compound.