5005-72-1

Basic information

• Product Name: Leptacline
• Synonyms: Leptacline;1-(Cyclohexylmethyl)piperidine;Piperidinomethylcyclohexane
• CAS NO: 5005-72-1
• Molecular Formula: C₁₂H₂₃N
• Molecular Weight: 0
• Mol File: 5005-72-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 244.6°C at 760 mmHg
• Flash Point: 111.9°C
• Appearance: /
• Density: 0.917g/cm³
• Vapor Pressure: 0.0302mmHg at 25°C
• Refractive Index: 1.488
• CAS DataBase Reference: Leptacline(CAS DataBase Reference)
• NIST Chemistry Reference: Leptacline(5005-72-1)
• EPA Substance Registry System: Leptacline(5005-72-1)

Safety Data

• Hazardous Substances Data: 5005-72-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H23N/c1-3-7-12(8-4-1)11-13-9-5-2-6-10-13/h12H,1-11H2

Upstream product

• 110-89-4 piperidine 
• 1192-37-6 methylenecyclohexane 
• 626-67-5 N-methylcyclohexylamine 
• 110-83-8 cyclohexene 
• 2591-86-8 N-Formylpiperidine 
• 2550-36-9 Cyclohexylmethyl bromide 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 100-49-2 cyclohexylmethyl alcohol 
• 201230-82-2 carbon monoxide 
• 7103-46-0 N-(cyclohexanecarbonyl)piperidine 
• 60-29-7 diethyl ether 
• 542-18-7 cyclohexyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 

Downstream Products

• 1072-95-3 cyclohexylmethyl chloride 

Relevant articles and documents

Titanium-Catalyzed Intermolecular Hydroaminoalkylation of Alkenes with Tertiary Amines

The first cationic titanium catalyst system for the intermolecular hydroaminoalkylation of alkenes with various tertiary alkylamines is presented. Corresponding reactions which involve the addition of the α-C?H bond of a tertiary amine across the C?C double bond of an alkene take place at temperatures close to room temperature with excellent regioselectivity to deliver the branched products exclusively. Interestingly, for selected amines, α-C?H bond activation occurs not only at N-methyl but also at N-methylene groups.

Heterogeneous Ru/TiO2for hydroaminomethylation of olefins: multicomponent synthesis of amines

Synthesizing aminesviathe hydroaminomethylation (HAM) reaction of olefins, a multicomponent reaction, has been regarded as one of the most attractive methods compared with the traditional methods considering the atom economy and environmental friendliness. However, the use of homogeneous catalysts, complex ligands containing diphosphine or nitrogen, and base or acid additives has severely hampered the utilization of these methods. Herein, an efficient heterogeneous Ru/TiO2-catalyzed HAM reaction of olefins is developed without any additives. Various amines, including secondary and tertiary amines, can be successfully obtained from olefins including aromatic and aliphatic olefins. Systematic studies demonstrate the lower electron density of Ruδ+and the higher number of acid sites of Ru/TiO2, leading to the high HAM reaction activity of olefins. Most importantly, nitrobenzene derivatives can also be transformed to the corresponding products over Ru/TiO2in excellent yields.

Mild Hydrogenation of Amides to Amines over a Platinum-Vanadium Bimetallic Catalyst

Hydrogenation of amides to amines is an important reaction, but the need for high temperatures and H2 pressures is a problem. Catalysts that are effective under mild reaction conditions, that is, lower than 30 bar H2 and 70 °C, have not yet been reported. Here, the mild hydrogenation of amides was achieved for the first time by using a Pt-V bimetallic catalyst. Amide hydrogenation, at either 1 bar H2 at 70 °C or 5 bar H2 at room temperature was achieved using the bimetallic catalyst. The mild reaction conditions enable highly selective hydrogenation of various amides to the corresponding amines, while inhibiting arene hydrogenation. Catalyst characterization showed that the origin of the catalytic activity for the bimetallic catalyst is the oxophilic V-decorated Pt nanoparticles, which are 2 nm in diameter.