500719-87-9Relevant articles and documents
Preparation of 4-trifluoroethylidene-1,3-dioxolane derivatives via new stable (trifluoromethyl)ethynylation reagent
Jeong, In Howa,Jeon, Sung Lan,Kim, Bum Tae
, p. 7213 - 7216 (2003)
Perfluoroalkylated 4-trifluoroethylidene-1,3-dioxolane derivatives 2a-q were prepared in excellent yields from the reaction of new stable (trifluoromethyl)ethynylation reagent 1a with 1.3 equiv. of TBAF at -15°C for 10 min, followed by treatment with 2 equiv. of phenyl perfluoroalkylated ketone derivatives at room temperature. The reaction of 1a with 1.3 equiv. of TBAF, followed by treatment with 1 equiv. of aldehyde or ketone at -15°C for 10 min and then with trifluoroacetophenone (1 equiv.) at room temperature afforded perfluoroalkylated 4-trifluoroethylidene-1,3-dioxolane derivatives 2t-u in moderate yields.
New approaches to β-trifluoromethylated enone derivatives
Jeong, In Howa,Jeon, Sung Lan,Kim, Myong Sang,Kim, Bum Tae
, p. 1629 - 1638 (2007/10/03)
β-Trifluoromethylated enaminones 1 were prepared stereospecifically or high stercoselectively in 31-92% yields from the reaction of Weinreb amides with trifluoropropynyl lithium, followed by quenching with H2O in the presence of amine derivativ
