500760-45-2

Basic information

• Product Name: Pyrazine, 3,6-diethoxy-2-[2-[4-(heptyloxy)phenyl]ethyl]-2,5-dihydro-2-methyl-5-(1- methylethyl)-, (2R,5R)-
• CAS NO: 500760-45-2
• Molecular Formula: C27H44N2O3
• Molecular Weight: 444.658
• Mol File: 500760-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrazine, 3,6-diethoxy-2-[2-[4-(heptyloxy)phenyl]ethyl]-2,5-dihydro-2-methyl-5-(1- methylethyl)-, (2R,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, 3,6-diethoxy-2-[2-[4-(heptyloxy)phenyl]ethyl]-2,5-dihydro-2-methyl-5-(1- methylethyl)-, (2R,5R)-(500760-45-2)
• EPA Substance Registry System: Pyrazine, 3,6-diethoxy-2-[2-[4-(heptyloxy)phenyl]ethyl]-2,5-dihydro-2-methyl-5-(1- methylethyl)-, (2R,5R)-(500760-45-2)

Safety Data

• Hazardous Substances Data: 500760-45-2(Hazardous Substances Data)

Upstream product

• 162358-40-9 2-(4-heptyloxyphenyl)ethyl iodide 
• 110117-71-0 (2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine 
• 500760-51-0 (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine 
• 74-88-4 methyl iodide 

Downstream Products

• 500760-49-6 [3-(4-heptyloxy-phenyl)-1-methyl-1-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)-propyl]-carbamic acid tert-butyl ester 
• 500760-46-3 tert-butyl [(1R)-3-[4-(heptyloxy)phenyl]-1-(hydroxymethyl)-1-methylpropyl]carbamate 
• 241476-71-1 (2R)-2-amino-4-[4-(heptyloxy)phenyl]-2-methylbutan-1-ol 

Relevant articles and documents

First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720

FTY720 is an immunosuppressant with a novel mode of action and is highly effective in animal models of transplantation and autoimmunity. Herein we describe the first asymmetric synthesis of chiral FTY720 analogues using the Sch?llkopf-protocol. We also describe a practical synthesis of the corresponding phosphates, which are essential tools for elucidation of FTY720's mechanism of action.