501121-34-2 Usage
Description
S,S-Atorvastatin, also known as (3S,5S)-Atorvastatin Sodium Salt, is a selective and competitive HMG-CoA reductase inhibitor. It is a white solid substance that belongs to a class of drugs specifically indicated for the treatment of hypercholesterolemia. S,S-Atorvastatin plays a crucial role in lowering elevated levels of LDL-cholesterol and triglycerides in patients, making it a vital pharmaceutical compound for managing cholesterol-related health issues.
Uses
Used in Pharmaceutical Industry:
S,S-Atorvastatin is used as a cholesterol-lowering agent for the treatment of hypercholesterolemia. It functions by inhibiting the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. This inhibition leads to a reduction in the levels of LDL-cholesterol (low-density lipoprotein cholesterol) and triglycerides in the blood, thus helping to prevent the development of atherosclerosis and other cardiovascular diseases.
Used in Cardiovascular Health:
S,S-Atorvastatin is used as a preventive measure for patients at risk of developing cardiovascular diseases due to high cholesterol levels. By reducing the levels of LDL-cholesterol and triglycerides, it helps to lower the risk of heart attacks, strokes, and other related health complications.
Used in Research and Development:
S,S-Atorvastatin is also utilized in the research and development of new drugs and therapies for cholesterol management and cardiovascular health. Its selective and competitive inhibition of HMG-CoA reductase makes it a valuable compound for studying the mechanisms of cholesterol synthesis and the development of novel treatments for hypercholesterolemia and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 501121-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,1,1,2 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 501121-34:
(8*5)+(7*0)+(6*1)+(5*1)+(4*2)+(3*1)+(2*3)+(1*4)=72
72 % 10 = 2
So 501121-34-2 is a valid CAS Registry Number.
InChI:InChI=1/C33H35FN2O5.Na/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;+1/p-1/t26-,27-;/m0./s1
501121-34-2Relevant articles and documents
METHODS FOR PROVIDING INTERMEDIATES IN THE SYNTHESIS OF ATORVASTATIN.
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, (2016/08/23)
The invention relates to the field of medicinal chemistry, In particular, it relates to methods for providing intermediates in the synthesis of Atorvastatin, a competitive inhibitor of HMG-Co A reductase. Provided is a process for providing a compound having a Formula (I) or a pharmaceutically acceptable salt, ester, amide or stereoisomer thereof, comprising reacting in a 4 component Ugi-reaction in a single reaction mixture the compounds of formula A, formula B, formula C and formula D.
